Abstract
Maintainance of a stable basal insulin level is important for glycemic control in treatment of diabetes mellitus. Recently introduced insulin degludec has the longest duration of action among basal insulin formulations. The purpose of this study was to assess changes in quality of life (QOL) associated with switching the basal insulin regimen to degludec in patients with type 1 and type 2 diabetes mellitus. This 24-week open-label intervention study included type 1 (n = 10) and type 2 (n = 20) diabetes mellitus patients, with adequately controlled hemoglobin A1c (HbA1c), who had received insulin glargine or detemir for at least 6 months. The primary outcome was change of QOL from baseline, as assessed by the Diabetes Therapy-Related QOL (DTR-QOL) application, after switching from glargine or detemir to degludec. HbA1c and other parameters were also assessed as secondary outcomes. QOL and HbA1c in patients with type 1 diabetes mellitus were unchanged during this study. In patients with type 2 diabetes mellitus, HbA1c did not change, but total DTR-QOL score was significantly improved from baseline after switching to degludec. The DTR-QOL Factor 2, "Anxiety and dissatisfaction with treatment", was significantly improved in patient...Continue Reading
References
Jul 16, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gurdeep Singh DhattBassam Bishawi
Jul 12, 2007·Diabetes Care·Francesca PorcellatiCarmine G Fanelli
Sep 13, 2011·Expert Opinion on Drug Delivery·David OyerDaniel A Nadeau
Sep 16, 2011·Current Medical Research and Opinion·T BaileyG Schmeisl
Oct 13, 2011·Current Medical Research and Opinion·S GargD Pollom
Feb 9, 2012·Journal of Medical Economics·Hitoshi Ishii
Apr 10, 2012·Pharmaceutical Research·Ib JonassenUlla Ribel
Apr 24, 2012·Lancet·Simon HellerUNKNOWN BEGIN Basal-Bolus Type 1 Trial Investigators
Jun 26, 2012·Diabetes, Obesity & Metabolism·T HeiseH Haahr
Oct 9, 2012·Diabetes Care·Bernard ZinmanUNKNOWN NN1250-3579 (BEGIN Once Long) Trial Investigators
Jan 24, 2013·Diabetes Care·Luigi MeneghiniUNKNOWN NN1250-3668 (BEGIN FLEX) Trial Investigators
Jul 12, 2013·Diabetes, Obesity & Metabolism·G KoehlerT R Pieber
Apr 8, 2014·Diabetes, Obesity & Metabolism·M J DaviesUNKNOWN BEGIN BB T1 Study Group
Apr 10, 2015·Acta Diabetologica·Tsuyoshi MashitaniHitoshi Ishii
Citations
Jan 17, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kohei KakuEmil Nørtoft
Dec 21, 2017·Postgraduate Medicine·Sarah L AndersonRobert J Tanenberg
Mar 2, 2018·Journal of Diabetes Investigation·Nagaaki TanakaUNKNOWN Positive SMBG Study Group Investigators
Jan 5, 2018·Current Medical Research and Opinion·Edurne LecumberriDomingo Orozco
Nov 3, 2017·Endocrine Journal·Mayuko OitaTatsuya Atsumi
Apr 17, 2020·European Journal of Clinical Investigation·Aastha MalikSatya Vati Rana
May 30, 2019·Diabetology International·Hitoshi IshiiBruce Crawford
Oct 9, 2020·Current Medical Research and Opinion·Kentaro TakiTomotaka Shingaki