Effect of switching basal insulin regimen to degludec on quality of life in Japanese patients with type 1 and type 2 diabetes mellitus

Journal of Pharmaceutical Health Care and Sciences
Morihiro OkadaYoshimichi Sai

Abstract

Maintainance of a stable basal insulin level is important for glycemic control in treatment of diabetes mellitus. Recently introduced insulin degludec has the longest duration of action among basal insulin formulations. The purpose of this study was to assess changes in quality of life (QOL) associated with switching the basal insulin regimen to degludec in patients with type 1 and type 2 diabetes mellitus. This 24-week open-label intervention study included type 1 (n = 10) and type 2 (n = 20) diabetes mellitus patients, with adequately controlled hemoglobin A1c (HbA1c), who had received insulin glargine or detemir for at least 6 months. The primary outcome was change of QOL from baseline, as assessed by the Diabetes Therapy-Related QOL (DTR-QOL) application, after switching from glargine or detemir to degludec. HbA1c and other parameters were also assessed as secondary outcomes. QOL and HbA1c in patients with type 1 diabetes mellitus were unchanged during this study. In patients with type 2 diabetes mellitus, HbA1c did not change, but total DTR-QOL score was significantly improved from baseline after switching to degludec. The DTR-QOL Factor 2, "Anxiety and dissatisfaction with treatment", was significantly improved in patient...Continue Reading

References

Jul 16, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gurdeep Singh DhattBassam Bishawi
Oct 13, 2011·Current Medical Research and Opinion·S GargD Pollom

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Citations

Jan 17, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kohei KakuEmil Nørtoft
Dec 21, 2017·Postgraduate Medicine·Sarah L AndersonRobert J Tanenberg
Apr 17, 2020·European Journal of Clinical Investigation·Aastha MalikSatya Vati Rana
May 30, 2019·Diabetology International·Hitoshi IshiiBruce Crawford

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