PMID: 7527044Aug 1, 1994Paper

Effect of sympathetic denervation on the relaxing responses of rabbit arterial smooth muscle

Journal of Autonomic Pharmacology
M VillanuevaW Osswald

Abstract

1. The present study reports on the influence of chemical denervation by 6-hydroxydopamine (6-OHDA) on the relaxing responses to carbachol, sodium nitroprusside, zaprinast, adenosine, forskolin and 3-isobutyl-1-methylxanthine (IBMX) of ring preparations of rabbit renal and femoral arteries. 2. Carbachol was found to induce a complete abolition of the tone induced by 5-hydroxytryptamine (0.1-1.0 microM), both in the renal and the femoral arteries. The profile of the carbachol-induced relaxation in both the renal and femoral arteries obtained from 6-OHDA-treated rabbits was similar to that observed in control animals; relaxing responses obtained with some of the concentrations of carbachol were, however, found to be greater (P < 0.01) in denervated arteries. Sodium nitroprusside was also found to be an effective relaxant agent in both renal and femoral arteries, though more potent in the former but was unaffected by denervation. Zaprinast relaxed both renal and femoral artery ring preparations, and again, no significant difference was observed between control and denervated animals. 3. The cyclic AMP-mediated relaxing responses to adenosine, forskolin and IBMX were found to be similar in renal and femoral arteries of control arte...Continue Reading

References

Jun 1, 1990·Journal of Autonomic Pharmacology·A Albino-TeixeiraI Azevedo
Oct 6, 1989·JAMA : the Journal of the American Medical Association·A G Gilman
Jul 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·D BrancoW Osswald

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