Effect of synbiotics in the treatment of smokers and nonsmokers with gingivitis: randomized controlled trial

Australian Dental Journal
Nuray ErcanMehmet Yalim

Abstract

To evaluate the efficacy of synbiotic tablets on the clinical and biochemical parameters of smokers and nonsmokers with gingivitis. Overall, 80 patients with gingivitis [40 smokers (+), 40 nonsmokers (-)] were randomly assigned to test (T) or control (C) groups. Four groups were defined: T(+), T(-), C(+), and C(-). The subjects daily chewed a synbiotic or placebo tablet for 30 days. The gingival crevicular fluid levels of interleukin (IL)-6, IL-8, and IL-10 were determined as the primary outcome variables. The clinical and biochemical parameters for all groups significantly reduced compared with the baseline (p < 0.05).While there were no significant differences between the groups for gingival index, the plaque index was significantly higher in both smoker groups than that in the T(-) group during the second month (p < 0.05). IL-8 levels in C(-) and IL-6 levels in both control groups were significantly higher than those in the T(+) group. The IL-10 levels in both control groups were significantly higher than those in the T(-) group during the second month (p < 0.05). Adjunctive synbiotic tablets significantly reduce subclinical therapeutic outcomes for both smokers and nonsmokers compared with placebo according to the biochemic...Continue Reading

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