Effect of synthetase inhibitors and receptor antagonists in antigen-induced contraction of human lung parenchyma

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
C FukushimaS Asai

Abstract

Chemical mediators induce bronchoconstriction, enhance vascular permeability, and promote inflammation. The use of synthetase inhibitors and receptor antagonists of these mediators may be useful in the treatment of asthma. We evaluated the role of chemical mediators in mite antigen-induced contraction in resected human lung parenchyma using synthetase inhibitors and receptor antagonists for these mediators. Resected human lung parenchymal specimens were passively sensitized with serum obtained from patients with asthma showing an IgE RAST score for mites > or = 5. The specimens were suspended in Magnus bath filled with buffer. After confirmation of contraction using PGF2 alpha, buffer or synthetase inhibitors or receptor antagonists of various chemical mediators were added. Contraction of parenchyma was induced by the addition of mite antigen, and the concentration of thromboxaneB2 (TXB2), leukotriene (LT), and histamine was measured before and after contraction. Thromboxane A2 (TXA2) synthetase inhibitors significantly inhibited TXB2 release but not contraction. Leukotriene synthetase inhibitors significantly inhibited both LT release and contraction. The magnitude of the inhibitory effect was in the order of LT receptor antag...Continue Reading

References

Jan 1, 1992·International Archives of Allergy and Immunology·A ArimuraM Harada
Jun 1, 1992·The American Review of Respiratory Disease·G L JonesP M O'Byrne
Nov 1, 1991·British Journal of Pharmacology·M G McKenniffP J Gardiner
Jun 1, 1990·The American Review of Respiratory Disease·K SladekJ R Sheller
Oct 1, 1989·The American Review of Respiratory Disease·M D LupinettiG A Fitzgerald
Mar 1, 1989·British Journal of Pharmacology·R A Coleman, R L Sheldrick
Jan 1, 1986·International Journal of Immunopharmacology·L Garcez Do CarmoB B Vargaftig
Jan 1, 1988·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·I IwamotoS Yoshida
Jun 1, 1987·The Journal of Allergy and Clinical Immunology·J P KempJ L Perhach
Apr 1, 1988·The Journal of Allergy and Clinical Immunology·S LamH Salari
Feb 1, 1983·Prostaglandins·R D KrellR E Giles
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·L M KuitertB Piotrowska
Jul 1, 1996·The Journal of Allergy and Clinical Immunology·S T HolgateA P Sampson
Dec 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C FukushimaK Hara
Jan 1, 1951·Acta Allergologica·L M ROSA, R J S McDOWALL

❮ Previous
Next ❯

Citations

Jan 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H MatsuseS Kohno
Dec 20, 2013·Expert Opinion on Pharmacotherapy·Hiroto Matsuse, Shigeru Kohno
Nov 27, 2019·Pharmacological Reviews·Stacy Gelhaus WendellCheng Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.