Effect of synthetic and natural secretin on the function of the exocrine pancreas in man

Digestion
P G Lankisch, W Creutzfeldt

Abstract

The action of synthetic and natural secretin on the human exocrine pancreas was compared. The trial was an intrasubject crossover comparison with randomized allocation of compounds in 12 healthy male subjects. No significant difference between compounds was found in bicarbonate, amylase and trypsin secretion after bolus injection. However, synthetic secretin evoked a significantly greater volume and amount of bicarbonate after infusion than the natural compound whilst no difference resulted in the other variables. It is concluded that synthetic secretin is suitable for testing the function of the exocrine pancreas.

Citations

Sep 1, 1982·Gut·P G Lankisch
Aug 23, 2005·Digestion·Werner CreutzfeldtPaul Georg Lankisch
Oct 3, 2002·The American Journal of Gastroenterology·Benedict M DevereauxStuart Sherman
Mar 19, 2003·Alimentary Pharmacology & Therapeutics·R S Chowdhury, C E Forsmark
May 19, 2005·Gastroenterología y hepatología·J Iglesias-García

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