PMID: 5576Jan 1, 1976

Effect of synthetic substance P on monoaminergic mechanisms in brain

Journal of Neural Transmission
T MagnussonK Folkers

Abstract

Synthetic substance P has been discovered to stimulate significantly the formation of dopa in the limbic, striatum, hemisphere and diencephalon regions of the brain and the lower brain stem. There was no effect upon 5-hydroxytryptophan formation or on tryptophan or tyrosine levels. After inhibition of monoamine synthesis by N'-(DL-SERYL)-N2-(2, 3, 4-trihydroxybenzyl)hydrazine, substance P significantly accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine. Substance P appears to stimulate monoaminergic neurons in the brain and to serve as an excitatory transmitter in nerve terminals impinging upon dopaminergic cell bodies. A similar stimulation of noradrenaline and 5-hydroxytryptamine indicate a similar transmitter role for noradrenergic and serotonergic neurons. These data strengthen questions about the possible clinical influence of substance P in disease states involving monoaminergic mechanisms including Parkinsonism and schizophrenia.

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Citations

Dec 27, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J A García-SevillaK Folkers
Nov 1, 1977·Pharmacology, Biochemistry, and Behavior·J M Goldstein, J B Malick
May 1, 1979·Pharmacology, Biochemistry, and Behavior·U Staubli, J P Huston
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·J L Haracz
Mar 1, 1983·Regulatory Peptides·K TreptowM Bienert
Mar 1, 1986·Neuroscience·J K MaiA C Cuello
Nov 11, 1998·Neuroscience and Biobehavioral Reviews·R B Raffa
Nov 1, 1977·Psychological Medicine·A Carlsson
Mar 1, 1979·British Journal of Pharmacology·T A James, M S Starr
Nov 1, 1982·The International Journal of Neuroscience·J FeigenbaumR Blass
Jun 28, 2016·PM & R : the Journal of Injury, Function, and Rehabilitation·Mithra B ManeyapandaNenad Brkic
Jan 1, 1980·Archives of Dermatological Research·R Wrench
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Related Concepts

Ro 4-4602
Brain
Dihydroxyphenylalanine Hydrochloride, (2:1)
Intropin
Norepinephrine, (+, -)-Isomer
Hydroxytryptamine
Hypothalamic Substance P
Neurohormones

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