Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat

European Journal of Pharmacology
Atsushi HashimotoYukie Chiba

Abstract

To obtain further insight into the distribution and metabolism of exogenous D-serine, we have investigated the effect of the intraperitoneal administration of D-serine (10 mmol/kg) on the concentrations of D- and L-serine in several brain areas and periphery of infant and adult rats. The administration produced a significant augmentation of the D-serine levels not only in the cortex but also in the hippocampus, striatum, cerebellum and periphery. The rapid decline in the enhanced D-serine levels was observed in the periphery and cerebellum, whereas the injection caused a prolonged elevation of the D-serine levels in the cortex and hippocampus. The application caused a slight increase in the L-serine levels in several brain areas and periphery 3 or 6 h after the injection, whereas a significant decrease in the L-serine concentration was observed in the periphery, diencephalon and cerebellum 3 or 7 days after the injection. Because a structural abnormality and N-methyl-D-aspartate (NMDA) receptor hypofunction has been demonstrated in the cortex and hippocampus of schizophrenic subjects, D-serine treatment may offer a new therapeutic approach to diseases related to the hypofunction of NMDA receptors such as schizophrenia.

References

Oct 1, 1977·Journal of Neurochemistry·W R Weimar, A H Neims
Oct 1, 1991·The American Journal of Psychiatry·D C Javitt, S R Zukin
Sep 4, 1991·European Journal of Pharmacology·A HashimotoK Takahashi
Jan 13, 1992·FEBS Letters·A HashimotoK Takahashi
Feb 1, 1989·Clinical Neuropharmacology·S I DeutschJ M Morihisa
Mar 1, 1966·Journal of Neurochemistry·A H NeimsJ D Smilack
May 1, 1984·Experimental and Clinical Endocrinology·H Bräunlich
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M J SchellS H Snyder
Jun 9, 1997·Biochemical and Biophysical Research Communications·D S Dunlop, A Neidle
Jul 1, 1997·Progress in Neurobiology·A Hashimoto, T Oka
Sep 1, 1997·Journal of Neurochemistry·K TakahashiT Nishikawa
Jan 16, 1998·European Journal of Pharmacology·J E HawkinsonP L Wood
Dec 4, 1998·Biological Psychiatry·G TsaiJ T Coyle
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·H WoloskerS H Snyder
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H WoloskerS H Snyder
Feb 13, 2001·Biochemical and Biophysical Research Communications·H TsuchidaT Nishikawa
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Guochuan Tsai, Joseph T Coyle

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Citations

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Jun 15, 2006·Cellular and Molecular Neurobiology·Joseph T Coyle
Jun 28, 2005·Molecular Genetics and Metabolism·Sabine A FuchsTom J de Koning
Sep 30, 2009·Molecular Psychiatry·L VerrallP J Harrison
Oct 18, 2006·Clinical and Experimental Pharmacology & Physiology·Mei WuYong-Xiang Wang
Jul 28, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rana RaisTakashi Tsukamoto
Feb 17, 2009·Biochemistry. Biokhimii︠a︡·S V Khoronenkova, V I Tishkov
Feb 15, 2011·Drug and Chemical Toxicology·Guliz ArmaganAyfer Yalcin
Jul 15, 2009·Neurobiology of Learning and Memory·Lakshmi KelamangalathJohn J Wagner
May 20, 2011·Journal of Neurochemistry·Yasuyuki KasaiKen-ichi Hosoya
Oct 29, 2005·Nuclear Medicine and Biology·Dagmar BauerKarl-Josef Langen
Aug 8, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tiziana AdagePaola Zaratin
Jul 12, 2016·International Journal of Molecular Sciences·Tsutomu SasakiTadahiro Kitamura
Mar 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Taban SeifF Woodward Hopf
Sep 2, 2008·Expert Review of Neurotherapeutics·Monsheel SodhiJames Meador-Woodruff
Jul 15, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tsutomu SasakiTadahiro Kitamura
Mar 31, 2018·Molecular and Cellular Neurosciences·Kirsten C SvaneBonnie L Firestein
Dec 12, 2020·The International Journal of Neuropsychopharmacology·Lili Veronika NagyIstván Hernádi
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