Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat

Experimental Neurology
Virginie ChauvelSylvie Multon

Abstract

The aura symptoms in migraine are most likely due to cortical spreading depression (CSD). CSD is favored by NMDA receptor activation and increased cortical excitability. The latter probably explains why migraine with aura may appear when estrogen levels are high, like during pregnancy. Kynurenic acid, a derivative of tryptophan metabolism, is an endogenous NMDA receptor antagonist whose cerebral concentrations can be augmented by systemic administration of its precursor L-kynurenine. To determine if exogenous administration of L-kynurenine is able to influence KCl-induced CSD in rat, if the effect is sex-dependent and if it differs in females between the phases of the estrous cycle. Adult Sprague-Dawley rats (n=8/group) received intraperitoneal (i.p.) injections of L-kynurenine (L-KYN, 300 mg/kg), L-KYN combined with probenecid (L-KYN+PROB) that increases cortical concentration of KYNA by blocking its excretion from the central nervous system, probenecid alone (PROB, 200 mg/kg) or NaCl. Cortical kynurenic acid concentrations were determined by HPLC (n=7). Thirty minutes after the injections, CSDs were elicited by application of 1M KCl over the occipital cortex and recorded by DC electrocorticogram. In NaCl and L-KYN groups, sup...Continue Reading

References

Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Lauritzen, A J Hansen
Jan 1, 1991·Journal of Clinical Epidemiology·B K RasmussenJ Olesen
Aug 1, 1984·Annals of Neurology·M A Moskowitz
Mar 1, 1981·Clinical Pharmacokinetics·R F CunninghamP G Dayton
Feb 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·H WolfR A Arend
Jun 2, 2000·Immunobiology·B WidnerD Fuchs
Feb 13, 2001·Cephalalgia : an International Journal of Headache·F GranellaG Napp
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·N HadjikhaniM A Moskowitz
Jun 26, 2001·The European Journal of Neuroscience·R CarpenedoF Moroni
Feb 1, 2002·Nature Medicine·Hayrunnisa BolayMichael A Moskowitz
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Robert Schwarcz, Roberto Pellicciari
May 22, 2003·Acta Neurologica Scandinavica·J IłzeckaW A Turski
Sep 1, 1964·The Journal of Clinical Investigation·A F MICHAELR A GOOD
Nov 13, 2003·Progress in Neurobiology·Jeremy J LambertJohn A Peters
Nov 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Cenk Ayata, Michael A Moskowitz
Feb 2, 2006·Annals of Neurology·Cenk AyataMichael A Moskowitz
Sep 29, 2006·The European Journal of Neuroscience·A BergerotP J Goadsby
Sep 30, 2006·Neurobiology of Disease·Martin SachsAli Gorji
Apr 27, 2007·Experimental Animals·Keiko SoneShin Tanaka
May 3, 2007·Annals of Neurology·Kevin C BrennanAndrew C Charles
Nov 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gilles J GuilleminBruce J Brew
Jul 4, 2008·American Journal of Physiology. Cell Physiology·William SilvermanGerhard Dahl
Mar 10, 2009·Journal of the Neurological Sciences·Eniko VamosLaszlo Vecsei

❮ Previous
Next ❯

Citations

Nov 2, 2014·Cancer Causes & Control : CCC·Sarah J LowryChristopher I Li
May 6, 2015·International Journal of Molecular Sciences·Zsuzsanna BohárLászló Vécsei
Sep 26, 2014·Expert Opinion on Drug Metabolism & Toxicology·János TajtiLászló Vécsei
Apr 14, 2015·Experimental Neurology·James D'AmourHelen E Scharfman
May 6, 2016·Frontiers in Immunology·Andrea I LoewendorfMike Harrington
May 27, 2014·Acta neurologica Belgica·Y FogangJ Schoenen
May 1, 2016·The Journal of Headache and Pain·Martina CurtoPaolo Martelletti
Jun 28, 2016·Neurotoxicity Research·J de BieG J Guillemin
Nov 20, 2016·European Journal of Clinical Investigation·Tomor HarnodChun-Hung Tseng
Jul 25, 2013·The Journal of Headache and Pain·Cinzia CostaPaola Sarchielli
Apr 21, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anna KlassEdgar Santos
Mar 7, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jan Hoffmann, Andrew Charles
Jan 27, 2018·Oncotarget·Alexander J SandweissTally M Largent-Milnes
Mar 9, 2021·Pharmacology Research & Perspectives·Mohammad Al-Mahdi Al-KaragholiMessoud Ashina

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.