Effect of systemic N-methyl-D-aspartate receptor antagonist (dextromethorphan) on primary and secondary hyperalgesia in humans

British Journal of Anaesthesia
S IlkjaerJ B Dahl

Abstract

Dextromethorphan is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist known to inhibit wind-up and central hyperexcitability of dorsal horn neurones. We studied 24 healthy, unmedicated male volunteers, aged 21-28 yr, in a randomized, double-blind, placebo-controlled, crossover study. Burn injuries were produced on the medial surface of the dominant calf with a 25 x 50 mm rectangular thermode. On three separate days, at least 1 week apart, subjects were given oral dextromethorphan 60 mg, 120 mg or placebo. Dextromethorphan reduced the magnitude of secondary hyperalgesia to pinprick but not to stroke. Dextromethorphan had no influence on primary hyperalgesia, pain during prolonged noxious heat stimulation or heat pain detection thresholds in undamaged skin. Side effects were frequent but clinically acceptable. The effects of dextromethorphan were in agreement with experimental studies indicating that dextromethorphan is a NMDA receptor antagonist. The effects of dextromethorphan in the burn injury model were similar to those of ketamine and distinct from those of local anaesthetics and opioids.

Citations

May 2, 2000·Diseases of the Colon and Rectum·S T LiuJ C Kang
Dec 23, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C S WongP L Tao
Jun 30, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A A WeinbroumR Ben-Abraham
Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Rashed A HasanDiana L Sigler
Nov 8, 2001·European Journal of Pharmacology·C G Parsons
Sep 29, 1999·Pharmacology & Therapeutics·A R Lloyd-Thomas
Jan 25, 2012·Nature Reviews. Gastroenterology & Hepatology·Pankaj Jay Pasricha
Oct 10, 2002·Regional Anesthesia and Pain Medicine·Takahiro UshidaHiroshi Yamamoto
Jun 21, 2011·Clinical and Experimental Pharmacology & Physiology·L K GuptaC D Tripathi
Aug 9, 2005·Postgraduate Medical Journal·M HeatleyC Weston
Apr 8, 2003·Annals of Surgical Oncology·Ron Ben AbrahamAvi A Weinbroum
Nov 13, 2001·American Journal of Clinical Dermatology·G GallagherJ Kinsella
Jun 10, 2010·Saudi Journal of Anaesthesia·Hossein MahmoodzadehNoshin Mosavi Beigi
Feb 8, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ralph-Thomas KieferRobert J Schwartzman
Apr 17, 2007·The Journal of Pain : Official Journal of the American Pain Society·Gretchen J SummerJon D Levine
Nov 23, 2006·The Journal of Pain : Official Journal of the American Pain Society·Adam R FrymoyerKarin Lottrup Petersen
Feb 3, 2006·Acta Anaesthesiologica Scandinavica·T H DuedahlJ B Dahl
Oct 21, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Takayuki AokiAkihiro Kaneko
Aug 24, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·P RichebéG Simonnet
Mar 15, 2005·Anesthesiology Clinics of North America·Ashraf S Habib, Tong J Gan
Mar 5, 2015·Acta Anaesthesiologica Scandinavica·V M RasmussenM U Werner
May 21, 2016·British Journal of Clinical Pharmacology·Guido van AmerongenJustin L Hay
Mar 30, 2011·Molecular Pain·Ruth RuscheweyhJürgen Sandkühler
Mar 29, 2000·Anesthesia and Analgesia·P E HessN E Oriol
Jan 3, 2014·Physiological Reviews·Emmanuel BourinetGerald W Zamponi
Jan 24, 2002·The Journal of Pharmacology and Experimental Therapeutics·Richard M AllenLinda A Dykstra
Sep 29, 2001·Acta Anaesthesiologica Scandinavica·J BrennumJ B Dahl

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