Effect of systemic oral administration of tetracycline on experimental gingivitis in golden hamsters

Nihon Shishubyo Gakkai kaishi
T Nomura

Abstract

Local and systemic administrations of tetracycline have been used in human periodontal treatment for conditions including juvenile periodontitis and rapidly progressive periodontitis, although microbiological effects of the treatment have not been clear. The effect of systemic oral administration of tetracycline on subgingival bacteria in experimental periodontal disease in hamsters as an animal model has not yet been reported. The aim of this study was to investigate changes in subgingival bacteria and bone resorption at the lower left first molar, and supragingival plaque formation on the lower right first molar in animals with (TC group) or without (Diet-2000 group) systemic oral administration of tetracycline hydrochloride 25 mg/kg/day in 20-day-old golden hamsters that mere fed a high sucrose diet (Diet-2000). Experimental periods were established as 15, 29, 43, 57, and 71 days. Supragingival plaque formation on the lingual surface on the lower right first molar in the Diet-2000 group gradually increased with time; that in the TC group was scarce and was not increased with time. Bone resorption at the lower left first molar in the Diet-2000 group proceeded rapidly with time, while that in the TC group was scarce. Total num...Continue Reading

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