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Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice

Neurotoxicity Research

Feb 11, 2018

Katarzyna SocałaPiotr Wlaz

Abstract

Tadalafil, a selective phosphodiesterase type 5 inhibitor, is a long-acting oral agent for the treatment of erectile dysfunction of multiple etiologies. Although generalized tonic-clonic seizures were reported in a healthy man after taking tadalafil, the influence of tadalafil on seizur...read more

Mentioned in this Paper

Study
Phosphodiesterase Inhibitors
Epilepsies, Myoclonic
Avoidance Learning
Laboratory Procedures
Tadalafil
Anticonvulsants
Phosphoric diester hydrolase
Erectile Dysfunction
Epilepsy
Paper Details
References
  • References33
  • Citations1
1234
  • References33
  • Citations1

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Effect of Tadalafil on Seizure Threshold and Activity of Antiepileptic Drugs in Three Acute Seizure Tests in Mice

Neurotoxicity Research

Feb 11, 2018

Katarzyna SocałaPiotr Wlaz

PMID: 29427285

DOI: 10.1007/s12640-018-9876-4

Abstract

Tadalafil, a selective phosphodiesterase type 5 inhibitor, is a long-acting oral agent for the treatment of erectile dysfunction of multiple etiologies. Although generalized tonic-clonic seizures were reported in a healthy man after taking tadalafil, the influence of tadalafil on seizur...read more

Mentioned in this Paper

Study
Phosphodiesterase Inhibitors
Epilepsies, Myoclonic
Avoidance Learning
Laboratory Procedures
Tadalafil
Anticonvulsants
Phosphoric diester hydrolase
Erectile Dysfunction
Epilepsy

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Epilepsy is a chronic neurological disorder characterized by unprovoked and recurrent seizures. Discover the latest research on factors and mechanisms that underlie epilepsy here.

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Progress in Neuro-psychopharmacology & Biological Psychiatry

Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice

Progress in Neuro-psychopharmacology & Biological PsychiatryJune 12, 2012
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Increased seizure susceptibility and other toxicity symptoms following acute sulforaphane treatment in mice

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Paper Details
References
  • References33
  • Citations1
1234
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  • Citations1
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