Abstract
Chemopreventive approaches for the treatment of breast cancer have been validated clinically and with in vitro studies. The combined action of tamoxifen/all-trans retinoic acid was advantageous in MCF-7 cells, reducing cell proliferation, Bcl-2 and c-Myc protein levels and increasing E-Cadherin protein levels and Gap junctional Intercellular Communication. We further investigated their combined effect in the presence of bradykinin, a pro-inflammatory agent, previously reported to contribute to the proliferation of breast cancer cells. Bradykinin increased MCF-7 cell proliferation, c-Myc levels and ERK1/2 activity. The co-incubation of bradykinin-MCF-7 cells with tamoxifen/all-trans retinoic acid reduced cell proliferation, ERK1/2 activity, as well as Bcl-2, c-Myc, and bradykinin receptor-2 levels, without altering the enhanced E-cadherin levels induced by tamoxifen/all-trans retinoic acid. We showed that the anti-tumoral effect of tamoxifen/all-trans retinoic acid is beneficial in MCF-7 breast cancer cells grown in a bradykinin-pro-mitogenic environment, an effect that might be, at least in part, through the MAPK pathway and B2-bradykinin receptor inhibition.
References
Oct 8, 1992·Nature·A FanidiG I Evan
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A E McEachernK Jarnagin
Sep 20, 1988·Biochemistry·Y P ChenL Chao
Mar 1, 1985·Peptides·R J Vavrek, J M Stewart
Sep 15, 1994·Genomics·J X MaL Chao
Jan 1, 1994·The Journal of Cell Biology·J C Reed
Mar 6, 1996·Journal of the National Cancer Institute·Y KangR R Perry
Dec 13, 1996·The Journal of Biological Chemistry·A BlaukatW Müller-Esterl
Mar 1, 1997·Kidney International·S S el-DahrW Müller-Esterl
May 1, 1997·Breast Cancer Research and Treatment·S J Nass, R B Dickson
Apr 16, 1998·Hypertension·H YuB I Freedman
Jan 7, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J B Pesquero, M Bader
Aug 13, 1999·The American Journal of Physiology·V VelardeA A Jaffa
Dec 22, 1999·Immunopharmacology·H MaedaT Akaike
May 16, 2000·Endocrine-related Cancer·H S Jacobs
Dec 6, 2000·British Journal of Cancer·S L DemingB J Trock
Jan 5, 2001·British Journal of Pharmacology·S Drube, C Liebmann
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
May 24, 2001·The Journal of Urology·L Barki-Harrington, Y Daaka
Dec 19, 2001·Biochemistry·A PizardR M Rajerison
Jun 8, 2002·Molecular and Cellular Biology·Madjid BenkoussaPhilippe Lefebvre
May 23, 2003·Journal of Cellular Biochemistry·Claudia G SáezM G Alvarez
Oct 8, 2003·Current Pharmaceutical Design·J M Stewart
Oct 8, 2003·Experimental Biology and Medicine·Rebecca SimsteinBarbara Beckman
Dec 11, 2003·The Journal of Veterinary Medical Science·Sohyun ParkSungIl Cho
Dec 31, 2003·Hypertension·Chun-Fang XiaJulie Chao
Feb 24, 2004·Biological Chemistry·Stéphanie MichineauRabary M Rajerison
Jul 29, 2004·Journal of Cellular Physiology·S GrecoSanto Marsigliante
Nov 2, 2004·Biological Research·Victoria VelardeAyad A Jaffa
Aug 5, 2005·The Journal of Endocrinology·S GrecoS Marsigliante
Jan 6, 2006·The Journal of Endocrinology·S GrecoS Marsigliante
Nov 14, 2006·Experimental Cell Research·Ying WangJen-Fu Chiu
May 16, 2007·Progress in Histochemistry and Cytochemistry·Lorenza González-MariscalErika Garay
Jan 10, 2008·International Immunopharmacology·Claudio M Costa-NetoPedro P C Souza
Citations
Jun 20, 2013·Journal of Bioenergetics and Biomembranes·Filomena S G SilvaJosé B A Custódio
May 29, 2013·European Journal of Pharmacology·Mariana P C RibeiroJosé B A Custódio
Jun 15, 2013·Life Sciences·Mariana P C RibeiroJosé B A Custódio
Jan 5, 2010·Neuropeptides·K de Picoli SouzaJ B Pesquero
Feb 22, 2012·Expert Opinion on Therapeutic Targets·Carlos D FigueroaKanti D Bhoola
Jun 3, 2014·Toxicology·Mariana P C RibeiroJosé B A Custódio
Dec 22, 2017·Oncotarget·Mahjabin KhanZhao-Xiang Bian
Aug 12, 2014·Oncology Reports·Guojun WangJunmin Song
Mar 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kuo-Shyan LinFrançois Bénard
Jun 24, 2015·Molecular Pharmaceutics·Guillaume AmourouxKuo-Shyan Lin