PMID: 9421103Jan 8, 1998Paper

Effect of tamoxifen on the pharmacokinetics of doxorubicin in patients with non-Hodgkin's lymphoma

Therapeutic Drug Monitoring
A el-YazigiF A Wahab

Abstract

The authors examined the effect of tamoxifen (TAM), a multiple-drug resistance modulator, on the pharmacokinetics of doxorubicin (DOX) in patients with non-Hodgkin's lymphoma treated according to the CHOP-protocol which included DOX, cyclophosphamide, vincristine, and prednisone. The dose of DOX was 50 mg/m2, but was reduced 25% if the patient was older than 60 years. Of these, 10 randomly-selected patients received a daily dose of 480 mg of TAM (Group-1) and 10 others did not (Group-2). Blood samples were collected at different time intervals, and DOX was measured in plasma by liquid chromatography. The concentration-time data of DOX exhibited the characteristics of the two-compartment open model well. The mean (SEM) values of alpha, beta, k12, k21, k10, Vc, Vss, AUC, total clearance, and mean residence time observed in Group-1 were 4.06 (0.96) hr(-1), 0.0395 (0.0068) hr(-1), 3.13 (0.79) hr(-1), 0.264 (0.052) hr(-1), 0.708 (0.19) hr(-1), 525 (156) l/m2, 1060 (163) l/m2, 1145 (234) microg x hr/l, 49.3 (8.5) l/hr x m2, and 26.8 (6.6) hours, respectively. Those in Group-2 were 4.99 (1.13) hr(-1), 0.0432 (0.0073) hr(-1), 2.46 (0.63) hr(-1), 0.111 (0.026) hr(-1), 2.46 (0.86) hr(-1), 231 (53) l/m2, 812 (149) l/m2, 1690 (276) microg ...Continue Reading

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J MillwardA L Harris
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·R PreissH Hüller
Jan 1, 1986·Cancer Chemotherapy and Pharmacology·D J KerrS B Kaye
Jul 1, 1988·Clinical Pharmacokinetics·P A SpethC Haanen
Nov 1, 1985·Journal of Pharmaceutical Sciences·A el-Yazigi, I Al-Saleh
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N L BartlettB I Sikic
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·E PommerenkeM Volm

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Citations

May 13, 2015·Biochimica Et Biophysica Acta·Samy A F Morad, Myles C Cabot
May 20, 2015·Biochemical Pharmacology·Jakub HofmanVladimir Wsol
Apr 3, 2015·Biology of Reproduction·Joanna Piasecka-SraderBrian K Petroff
Mar 27, 2015·Biology of Reproduction·Alison Y Ting, Brian K Petroff
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beth OvermoyerScot C Remick

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