Effect of taurine on angiotensin II-induced hypertrophy of neonatal rat cardiac cells

Journal of Cardiovascular Pharmacology
K TakahashiJ Azuma

Abstract

The effect of taurine on angiotensin II-induced hypertrophy of cultured neonatal rat heart cells (myocytes and nonmyocytes) was examined. Angiotensin II (1-100 nM) alone caused an increase in the rate of protein synthesis of myocytes without changing the rate of DNA synthesis and cell number. It mediated increases in DNA synthesis and cell number in nonmyocytes. Furthermore, at the lower concentration of 1 nM, it induced c-fos and c-jun expression in both cultured myocytes and nonmyocytes. Exposure of the cells to taurine (20 mM) in the absence of angiotensin II had no effect on either hyperplastic growth or immediate early response gene expression by the two types of cultured cardiac cells. However, myocytes pretreated for 24 h with 20 mM taurine exhibited reduced responsiveness to angiotensin II (1 nM), resulting in lower levels of angiotensin II-mediated stimulation in protein synthesis, and immediate early response gene expression was attenuated. Similarly, taurine treatment of nonmyocytes reduced the degree of hyperplastic growth (DNA synthesis and cell number) and immediate early response gene expression stimulated by angiotensin II. Finally, taurine partially prevented the increase in intracellular free calcium [Ca2+]i m...Continue Reading

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Citations

Mar 11, 2003·The Journal of Physiology·N C SundgrenK L Thornburg
Dec 12, 2012·Amino Acids·Shigeru Murakami
Dec 12, 2012·Amino Acids·Masato ImaeShigeru Murakami
Jul 28, 1999·Clinical and Experimental Hypertension : CHE·K Arakawa
Jul 11, 2006·Medical Hypotheses·Mark F McCarty
May 29, 2004·Journal of Cardiovascular Pharmacology·Tomoka TakataniJunichi Azuma
Feb 27, 2016·Food & Function·Wen ChenJing Zhang
Sep 29, 2019·Canadian Journal of Physiology and Pharmacology·Ghassan BkailyDanielle Jacques
Apr 30, 2003·Journal of Cardiovascular Pharmacology·Stephen SchafferJunichi Azuma
Apr 30, 2003·Journal of Cardiovascular Pharmacology·Kyoko TakahashiJunichi Azuma
Sep 23, 2020·Nutrients·Tawar QaradakhiAnthony Zulli
Dec 20, 2020·International Journal of Environmental Research and Public Health·Mariarita BrancaccioOlga Scudiero
Jun 25, 1999·Biochemical and Biophysical Research Communications·K TakahashiJ Azuma

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