PMID: 39994Aug 1, 1979

Effect of taurine on release of 3H-GABA by depolarizing stimuli from superfused slices of rat brain cerebral cortex in vitro

The Journal of Pharmacy and Pharmacology
M J Leach


The effect of taurine on potassium (30 mM), veratrine (10 micrograms ml-1) and ouabain (100 microM) induced release of 3H-GABA from superfused slices of rat brain cerebral cortex had been studied. Taurine (10--100 mM) potentiated K+-induced release of 3H-GABA but was more potent in potentiating veratrine- and ouabain-induced release, having significant effects at 5 mM and 1 mM respectively. The potentiation of stimulus induced release does not appear to be due to inhibition of reuptake and the effect is consistent with both a 'modulatory' role and anticonvulsant action for taurine.


Aug 11, 1981·Molecular and Cellular Biochemistry·R L Macdonald, A B Young
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·A P Ferko, E Bobyock
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·S Hashimoto-KitsukawaH Aihara
Jan 1, 1993·Pharmacology, Biochemistry, and Behavior·R Liljequist
Jan 1, 1989·Progress in Neurobiology·R J Huxtable
Jan 1, 1992·Progress in Neurobiology·P Saransaari, S S Oja
Jan 1, 1988·The International Journal of Neuroscience·P Kontro, S S Oja
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·M J LeachM Nobbs
Nov 1, 1988·Journal of Neurochemistry·P S WhittonR H Strang
May 1, 1981·British Journal of Pharmacology·R J Harman, G G Shaw


Jun 1, 1978·Journal of Neurochemistry·P Kontro, S S Oja
Sep 1, 1975·Life Sciences·A BarbeauR F Butterworth
Dec 1, 1975·Journal of Neurochemistry·P Krogsgaard-Larsen, G A Johnston
Nov 1, 1974·Journal of Neurochemistry·F CrabaiG Pepeu
Jan 1, 1973·Journal of Neurochemistry·D M CrnicR W Cutler
Aug 1, 1973·Journal of Neurochemistry·J S De Belleroche, H F Bradford

Related Concepts

ATP8A2 gene
Taurine, Monopotassium Salt
IL17F gene
ATP8A2 wt Allele

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.