PMID: 39994Aug 1, 1979

Effect of taurine on release of 3H-GABA by depolarizing stimuli from superfused slices of rat brain cerebral cortex in vitro

The Journal of Pharmacy and Pharmacology
M J Leach

Abstract

The effect of taurine on potassium (30 mM), veratrine (10 micrograms ml-1) and ouabain (100 microM) induced release of 3H-GABA from superfused slices of rat brain cerebral cortex had been studied. Taurine (10--100 mM) potentiated K+-induced release of 3H-GABA but was more potent in potentiating veratrine- and ouabain-induced release, having significant effects at 5 mM and 1 mM respectively. The potentiation of stimulus induced release does not appear to be due to inhibition of reuptake and the effect is consistent with both a 'modulatory' role and anticonvulsant action for taurine.

References

Aug 11, 1981·Molecular and Cellular Biochemistry·R L Macdonald, A B Young
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·A P Ferko, E Bobyock
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·S Hashimoto-KitsukawaH Aihara
Jan 1, 1993·Pharmacology, Biochemistry, and Behavior·R Liljequist
Jan 1, 1989·Progress in Neurobiology·R J Huxtable
Jan 1, 1992·Progress in Neurobiology·P Saransaari, S S Oja
Jan 1, 1988·The International Journal of Neuroscience·P Kontro, S S Oja
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·M J LeachM Nobbs
Nov 1, 1988·Journal of Neurochemistry·P S WhittonR H Strang
May 1, 1981·British Journal of Pharmacology·R J Harman, G G Shaw

Citations

Jun 1, 1978·Journal of Neurochemistry·P Kontro, S S Oja
Sep 1, 1975·Life Sciences·A BarbeauR F Butterworth
Dec 1, 1975·Journal of Neurochemistry·P Krogsgaard-Larsen, G A Johnston
Nov 1, 1974·Journal of Neurochemistry·F CrabaiG Pepeu
Jan 1, 1973·Journal of Neurochemistry·D M CrnicR W Cutler
Aug 1, 1973·Journal of Neurochemistry·J S De Belleroche, H F Bradford

Related Concepts

ATP8A2 gene
Taurine, Monopotassium Salt
Anticonvulsants
IL17F gene
Cevadine
Potassium
Ouabain
Reuptake
Taurine
ATP8A2 wt Allele

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