PMID: 8583148Nov 1, 1995Paper

Effect of tauroursodeoxycholic acid on bile flow and calcium excretion in ischemia-reperfusion injury of rat livers

Journal of Hepatology
T OnoT Nakamura

Abstract

Tauroursodeoxycholic acid is known to have a hepatoprotective action in cholestatic disorders. We evaluated whether oral pretreatment with tauroursodeoxycholic acid could protect the liver from ischemia-reperfusion injury, with particular regard to its effect on bile flow and biliary calcium excretion. A 1-hour in vivo ischemia-reperfusion model of 70% of the lobes of rat liver was used. Animals were divided into six groups (each group; n = 8); a non-ischemia sham group (CS), a control group without bile acids (CON), and 4 bile acid groups; 10 mg/kg and 50 mg/kg (U10, U50), taurocholic acid 10 mg/kg (CA10) and tauroursodeoxycholic acid 10 mg/kg (CD10). Bile acids were given orally for 7 days before operation. Three hours after reperfusion, oral bile acid pretreatment failed to reduce the hepatic ischemia-reperfusion injury biochemically, but histological improvement was observed in the tauroursodeoxycholic acid groups. After reperfusion, tauroursodeoxycholic acid significantly increased bile flow from the ischemic liver, and also significantly increased serum calcium concentration. Although tauroursodeoxycholic acid did not change biliary calcium concentration, it significantly enhanced total biliary calcium output during reper...Continue Reading

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Citations

Nov 5, 1999·Archives of Pharmacal Research·W Y LeeS M Lee
Jan 5, 2010·Journal of Ocular Biology, Diseases, and Informatics·Jeffrey H BoatrightMachelle T Pardue
Sep 8, 1998·International Journal of Immunopharmacology·H Farghali, K Masek
Jun 8, 2013·Basic Research in Cardiology·Elise BelaidiMichel Ovize
Nov 3, 2010·Journal of Molecular and Cellular Cardiology·Asli F Ceylan-IsikJun Ren
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cecilia M P RodriguesClifford J Steer
Sep 27, 2005·Cell Transplantation·Pamela H LaiWei-Shou Hu
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Luigi AccatinoCecilia S Koenig

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