Effect of tea polyphenols and tea pigments on the inhibition of precancerous liver lesions in rats

Nutrition and Cancer
Y GongJ Chen

Abstract

The objective of this study was to investigate the inhibitory effect of tea components, tea polyphenols and tea pigments, on precancerous liver lesions in rats. A rat liver precancerous lesion model was established by multiple low-dosage N-nitrosodiethylamine (NDEA) injections, followed by intraperitoneal CCl4 injection and partial hepatectomy (PH). Tea pigments (0.1%) or tea polyphenols (0.1%) were given to Wistar rats in drinking water during the eight weeks of the experiment. The number and area of glutathione S-transferase Pi-positive foci in the rat liver were used as biomarkers of precancerous liver lesions. Western and Northern blot techniques were used to detect rat liver GST-Pi expression at the protein and mRNA levels. At the end of the experiment, tea polyphenols and tea pigments significantly decreased the number and area of GST-Pi-positive foci that were overexpressed in the NDEA-CCl4-PH-treated rats compared with the positive control group. The results also showed that GST-Pi mRNA and protein expression increased significantly in the NDEA-CCl4-PH-treated group, which is consistent with the changing of GST-Pi-positive foci. Tea pigments and tea polyphenols had an inhibitory effect on the overexpression of GST-Pi mR...Continue Reading

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Citations

Dec 25, 2007·Antioxidants & Redox Signaling·Naghma KhanHasan Mukhtar
Dec 2, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jeanine L MarnewickWentzel C A Gelderblom
Oct 28, 2019·International Journal of Molecular Sciences·Xiangbing MaoJun He
Sep 13, 2003·World Journal of Gastroenterology : WJG·Yun Lu, Li-Qun Wu

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