Effect of telithromycin and azithromycin on nasopharyngeal bacterial flora in patients with acute maxillary sinusitis

Archives of Otolaryngology--head & Neck Surgery
Itzhak Brook, Jeffrey N Hausfeld

Abstract

To explore the efficacy of the ketolide telithromycin compared with azithromycin in eradicating S pneumoniae from the nasopharynx of adults with acute maxillary sinusitis. The growing resistance of Streptococcus pneumoniae to penicillin and macrolides brought about the development of a new class of antibiotics-the ketolides-that are effective against resistant pneumococci. Otolaryngology clinic. One-hundred five patients with acute maxillary sinusitis. Nasopharyngeal cultures were obtained before therapy and 10 to 12 days after initiation of treatment. Fifty-nine patients were treated with 500 mg of azithromycin daily for 3 days and 46 were treated with 800 mg of telithromycin daily for 5 days. Sixty-seven potential pathogens were recovered prior to initiation of therapy in 57 patients, 32 treated with telithromycin and 25 treated with azithromycin: S pneumoniae (31 isolates), Haemophilus influenzae (non-type b) (13), Staphylococcus aureus (8), Streptococcus pyogenes (8), and Moraxella catarrhalis (7). The distribution of the pathogens was similar in both groups. The number of S pneumoniae isolates in the azithromycin group was reduced following treatment from 14 to 8 (43% reduction), and 5 of these 8 isolates were resistant to...Continue Reading

Citations

Jan 19, 2008·Expert Opinion on Pharmacotherapy·Françoise Van BambekePaul M Tulkens
Jan 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mark S La Shell, Michael S Tankersley
Oct 17, 2015·The Cochrane Database of Systematic Reviews·Anneli Ahovuo-SalorantaMarjukka Mäkelä
Jan 11, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery

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