PMID: 8967356Apr 1, 1996Paper

Effect of temperature on myocardial infarction in swine

The American Journal of Physiology
D J DunckerR J Bache

Abstract

Body core temperature in the normothermic range alters infarct size in rabbits. Moreover, temperature may modulate the protection by adenosine during a coronary artery occlusion. We investigated the effect of core temperature within the normothermic range (35-39 degrees C) on myocardial infarct size produced by a 45-min coronary occlusion in open-chest swine (n = 10), and we determined whether adenosine blockade with 8-phenyltheophylline and adenosine deaminase increased infarct size in the normothermic range (n = 9). After 4 h of reperfusion the area at risk and infarct size were determined with Evans blue dye and triphenyltetrazolium chloride. Infarct size strongly correlated with temperature (r2 = 0.71, P = 0.0001) so that at 35 degrees C no infarction occurred and with each 1 degree C increase in temperature 20% of the area at risk became infarcted. In contrast, neither the low levels of collateral flow (0.03 +/- 0.01 ml.min-1.g-1) nor the rate-pressure product correlated with infarct size. In the normothermic range, adenosine blockade had no effect on infarct size. The data demonstrate that temperature can exert a profound effect on infarct size but fail to demonstrate a protective effect on endogenous adenosine at normoth...Continue Reading

Citations

Mar 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Daphne MerkusDirk J Duncker
Dec 20, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Xian-Liang TangRoberto Bolli
Dec 19, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Zuo-Hui ShaoTerry L Vanden Hoek
Feb 28, 2007·BMC Cardiovascular Disorders·Goran K OlivecronaDavid Erlinge
Nov 1, 1996·Circulation·B C GhoP D Verdouw
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Michael W DaeCarol A Stillson
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Daniel C SiggPaul A Iaizzo
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y T XuanR Bolli
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·E KodaniR Bolli
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T EtohF G Spinale
Jul 23, 2013·American Journal of Physiology. Heart and Circulatory Physiology·André UitterdijkHeleen M M van Beusekom
Jul 15, 2015·Mediators of Inflammation·Matthias WeusterIngo Witte
Oct 8, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Richard W B van DuinDaphne Merkus
Jan 12, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Maaike Te Lintel HekkertDirk J Duncker
Oct 16, 2020·Basic Research in Cardiology·M V BasalayS M Davidson
Mar 5, 2021·Frontiers in Cardiovascular Medicine·Kelly P YamadaKiyotake Ishikawa
May 26, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marko NocThomas R Keeble

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