PMID: 15338845Sep 2, 2004Paper

Effect of tenofovir disoproxil fumarate on the pharmacokinetics and pharmacodynamics of total, R-, and S-methadone

Pharmacotherapy
Patrick SmithJohn F Flaherty

Abstract

To evaluate the potential effect of tenofovir disoproxil fumarate (DF) on the pharmacokinetics of methadone. Phase I, open-label, fixed-sequence, pharmacokinetic drug-drug interaction study. Clinical research center. Fourteen volunteers receiving stable methadone maintenance therapy who were not infected with the human immunodeficiency virus. Tenofovir DF was added to the subjects' methadone regimens. The pharmacokinetics of total, R-, and S-methadone were evaluated at baseline and after 2 weeks of daily tenofovir DF coadministration with a light meal. Steady-state tenofovir DF pharmacokinetics were evaluated at day 15. Bioequivalence testing was conducted of total, R-, and S-methadone area under the serum or plasma concentration-time curve during the 24-hour dosing interval at steady state (AUCss) and maximum concentration in serum or plasma (Cmax). Subjects were evaluated for changes in methadone pharmacodynamics by the Short Opiate Withdrawal Scale (SOWS) and pupillary diameter measurements at frequent intervals. Coadministration with tenofovir DF did not affect the pharmacokinetics of methadone. Geometric mean R-methadone systemic exposures, AUCss and Cmax, differed by 5% or less when methadone was dosed with tenofovir DF. ...Continue Reading

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Citations

Nov 13, 2014·JAAPA : Official Journal of the American Academy of Physician Assistants·Jonathan Baker, Kevin Michael OʼHara
Apr 4, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Douglas J WeschulesSteven Richeimer
Feb 7, 2009·Enfermedades infecciosas y microbiología clínica·Josep Mallolas
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Feb 7, 2009·Enfermedades infecciosas y microbiología clínica·José Ramón AzanzaAlmudena Gómez-Giu

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