PMID: 44669Oct 1, 1979

Effect of terbutaline, a beta 2-adrenergic receptor stimulating compound, on cutaneous reponses to histamine, allergen, compound 48/80, and trypsin

Allergy
R GrönnebergO Hägermark

Abstract

The beta-adrenoceptor stimulating agent terbutaline (2 ng-2 microgram) injected intradermally in eight atopic subjects produced a dose-dependent inhibition of the skin reactions induced by subsequently injected allergen. After injection of 0.5 microgram terbutaline inhibition of the flare and weal responses was demonstrable throughout the observation period of 90 min. The flare response induced by histamine, the histamine liberator compound 48/80 and the proteolytic enzyme trypsin was not inhibited by terbutaline in the doses used, suggesting a selective action of terbutaline on the allergen-induced response. The weal response elicited by histamine and compound 48/80 was slightly reduced by 2 microgram terbutaline. It is suggested that pretreatment of the skin with terbutaline interferes with the ability of the cutaneous mast cells to respond to challenge with allergen and that terbutaline produces this effect in doses lower than those needed to counteract the permeability increasing effect of released mediator substances.

References

May 1, 1976·The Journal of Allergy and Clinical Immunology·N LamkinH Robinson
Mar 1, 1978·British Journal of Pharmacology·S R O'Donnell, C G Persson
Nov 1, 1975·The Journal of Allergy and Clinical Immunology·J A KramK L Melmon
Oct 1, 1978·The Journal of Allergy and Clinical Immunology·S A ImbeauC E Reed
Aug 30, 1968·Science·L M Lichtenstein, S Margolis
Dec 1, 1973·The Journal of Allergy and Clinical Immunology·R H ShereffH Robinson
Sep 1, 1969·The Journal of Cell Biology·G MajnoM Leventhal
May 1, 1950·The Journal of Allergy·M M MOSKO, R B MARSHALL

Related Concepts

Adrenergic beta-Agonists
Allergens
p-Methoxy-N-methylphenethylamine
Dose-Response Relationship, Immunologic
Ceplene
Immediate Hypersensitivity
Intradermal Injection
Skin
Terbutalin von ct
Trypure

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