Effect of testosterone and estrogen supplementation on the resistance to systemic Candida albicans infection in mice

Heliyon
Melissa Arroyo-MendozaNancy E Buckley

Abstract

Candida species are the 4th leading cause of nosocomial infections in the US affecting both men and women. Since males of many species can be more susceptible to infections than females, we investigated whether male mice were more susceptible to systemic Candida albicans (C. albicans) infection and if sex hormones were responsible for sex-dependent susceptibility to this infection. Non-gonadectomized or gonadectomized mice were supplemented with sustained release 5α-dihydrotestosterone (5αDHT) or 17-β-estradiol (E2) using subcutaneous pellet implantation. Mice were challenged intravenously with 5 × 105C. albicans/mouse seven days after pellet implantation and monitored for survival and weight change. We observed that male mice were more susceptible to systemic C. albicans infection than female mice while gonadectomized male mice were as resistant to the C. albicans infection as female mice. 5αDHT supplementation of gonadectomized female or male mice increased their susceptibility to the yeast infection while E2 supplementation of gonadectomized male mice did not increase their resistance to the infection. Overall, our results strongly suggest that testosterone plays an important role in decreasing resistance to systemic C. albi...Continue Reading

References

Mar 1, 1972·Infection and Immunity·D Rifkind, J A Frey
May 1, 1972·Infection and Immunity·D Rifkind, J A Frey
Apr 1, 1994·Baillière's Clinical Endocrinology and Metabolism·V A Randall
Aug 15, 2000·Neuroscience and Biobehavioral Reviews·S L Klein
Jul 27, 2001·Best Practice & Research. Clinical Endocrinology & Metabolism·Y Jin, T M Penning
Oct 29, 2004·The Journal of Antimicrobial Chemotherapy·Jill P Adler-MooreRichard T Proffitt
Sep 28, 2007·Biochemical Pharmacology·Xingguo ChengCurtis D Klaassen
Oct 4, 2011·Journal of Leukocyte Biology·Miguel RellosoRosalia Diez-Orejas
Jan 19, 2012·Infection and Immunity·Shih-Chin ChengMihai G Netea
Feb 14, 2012·Methods in Molecular Biology·Alieke G VonkBart Jan Kullberg
May 23, 2012·Cell Host & Microbe·Nydiaris Hernández-Santos, Sarah L Gaffen
Feb 25, 2015·Cellular Immunology·Abhishek TrigunaiteTrine N Jørgensen
Feb 28, 2015·Aging Cell·Carmen Giefing-KröllBeatrix Grubeck-Loebenstein
Apr 23, 2015·International Reviews of Immunology·Leonardo MirandolaMaurizio Chiriva-Internati
Jul 8, 2015·Eukaryotic Cell·Shelby J Priest, Michael C Lorenz
Feb 20, 2016·PLoS Pathogens·Landon G vom Steeg, Sabra L Klein
Apr 15, 2016·Virulence·Yulin QinYongbing Cao
Aug 23, 2016·Nature Reviews. Immunology·Sabra L Klein, Katie L Flanagan
Nov 7, 2016·Hormones and Behavior·Landon G Vom Steeg, Sabra L Klein
Nov 22, 2016·Nature Reviews. Microbiology·Suzanne M NobleJessica N Witchley
Jun 20, 2019·International Journal of Molecular Sciences·Adrian M PiliponskyNicholas J Shubin
Sep 27, 2019·MMWR. Surveillance Summaries : Morbidity and Mortality Weekly Report. Surveillance Summaries·Mitsuru TodaSnigdha Vallabhaneni

❮ Previous
Next ❯

Software Mentioned

ENVIGO
GraphPad Prism

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.