Effect of testosterone on compensatory renal hypertrophy in the rat

Endocrinology
D SchlondorffS Korth-Schutz

Abstract

The effect of testosterone on compensatory renal hypertrophy (CRH) remains controversial. We therefore examined the effect of exogenous testosterone on CRH in adult male and female rats after unilateral nephrectomy. The influence of endogenous testosterone was studied by comparing the degree of CRH in normal male, castrated male, and in testosterone receptor deficient male pseudohermaphrodite rats. Furthermore, serial determinations of serum testosterone levels were performed after unilateral nephrectomy in male rats. Compensatory renal hypertrophy was comparable between male rats--with or without exogenous testosterone administration--and between normal male, castrated male, and psuedohermaphrodite male rats. In contrast, exogenous testosterone administration in female rats enhanced CRH. Serum testosterone levels fell markedly after unilateral nephrectomy or sham surgery, but increased to 183% and 234% of control values at 1 and 2 days after surgery in the unilaterally nephrectomized rats. At no time, however, did they exceed the range of normal values. The results indicate a different effect of testosterone on CRH in male and female rats.

Citations

Feb 15, 1982·Life Sciences·F StéphanM H Köll-Back
Aug 5, 1999·Kidney International·H ZhangH Makino
Jul 1, 1982·Archives internationales de physiologie et de biochimie·A Goldraij, M L Rins de David
Mar 1, 1991·Kidney International·G Wolf, E G Neilson
Jun 1, 1986·Kidney International·J R Jobin, J P Bonjour
Nov 1, 1986·Kidney International·N NarasimhanW M Bennett
Mar 1, 1986·Kidney International·L G Fine
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Feb 27, 2018·Journal of the American Heart Association·Samyuktha Muralidharan PillaiFrançois Verrey
Mar 4, 2000·Endocrinology·S E Mulroney, C Pesce

Related Concepts

Hypertrophy
Kidney
Nephrectomy
Intersexuality
Sterotate

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