Effect of testosterone on potassium channel opening in human corporal smooth muscle cells

The Journal of Sexual Medicine
Deok Hyun HanSung Won Lee

Abstract

In humans, the role of testosterone in sexual functions, including sexual desire, nocturnal penile erections, and ejaculatory volume, has been relatively well established. However, the effects of testosterone on intrapenile structure in humans remains controversial. We assessed the direct effects of testosterone on potassium channels in human corporal smooth muscle cells, in an effort to understand the mechanisms inherent to the testosterone-induced relaxation of corporal smooth muscle cells at the cellular and molecular levels. Methods. We conducted electrophysiologic studies using cultured human corporal smooth muscle cells. We evaluated the effects of testosterone on potassium channels-BK(Ca) and K(ATP) channels-by determining the whole-cell currents and single-channel activities. For the electrophysiologic recordings, whole-cell and cell-attached configuration patch-clamp techniques were utilized. Changes in whole-cell currents and channel activities of BK(Ca) and K(ATP) channels by testosterone. Results. Testosterone (200 nM) significantly increased the single-channel activity of calcium-activated potassium (BK(Ca)) channels and whole-cell K(+) currents by 443.4 +/- 83.4% (at +60 mV; N = 11, P < 0.05), and this effect was ...Continue Reading

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Citations

Jun 24, 2011·International Journal of Impotence Research·H H SungS W Lee
Dec 18, 2009·Southern Medical Journal·Felix Boon Bin Yap
Nov 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Viju DeenadayaluRichard E White
Feb 7, 2009·Physiology·Shangwei HouToshinori Hoshi
Dec 10, 2015·The Journal of Sexual Medicine·Biljana MusickiArthur L Burnett
Jan 12, 2010·The Journal of Sexual Medicine·Jae Hun JungSung Won Lee
Jan 31, 2012·Steroids·Vítor S FernandesMedardo Hernández
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Apr 24, 2020·The Journal of Biological Chemistry·Wei ShiJiangping Wu
Nov 15, 2020·Journal of the International Society of Sports Nutrition·Manuel Vicente Garnacho-CastañoLorena Molina-Raya
Jul 16, 2009·Current Opinion in Obstetrics & Gynecology
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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