PMID: 3754499Jun 1, 1986Paper

Effect of testosterone treatments for varying periods on autoimmune development and on specific infiltrating leukocyte populations in the thyroid gland of obese strain chickens

Clinical Immunology and Immunopathology
W C Gause, J A Marsh

Abstract

Spontaneous autoimmune thyroiditis (SAT) is detectable by 2 weeks of age in the obese (OS) strain of chicken, and by 6 weeks virtually all of these animals have severe lymphoid infiltration of the thyroid. During the interval from hatching to 6 weeks of age, testosterone implants were administered for varying periods. All treatment groups were terminated at 6 weeks. Testosterone administered shortly after hatching increased thymus weight, depressed bursa weight, and reduced the severity of SAT, as measured by lymphoid infiltration of the thyroid and circulating thyroglobulin autoantibody concentrations. Birds supplemented with testosterone at later intervals exhibited depressed bursa and thymus weight; however, the severity of SAT was not affected. In a second experiment, the treated group was administered testosterone for the first 2 weeks after hatching. Thyroids were histologically examined at 2 and 6 weeks using a panel of five monoclonal antibodies (anti-Ia, anti-IgM, anti-IgG, anti-T cell, and antithymocyte). Compared with untreated controls, testosterone treatment reduced the frequency of Ia+ cells, T cells, and IgG+ cells in the thyroid. This treatment did not affect the frequency of IgM+ cells, and perhaps slightly inc...Continue Reading

References

Nov 1, 1972·The Journal of Experimental Medicine·D Eidinger, T J Garrett

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Citations

Sep 30, 2005·Proceedings. Biological Sciences·Wendt MüllerHeli Siitari
Jan 15, 1997·Annals of the New York Academy of Sciences·J C WingfieldN Hillgarth
Dec 23, 2006·The Journal of Animal Ecology·Juan A FargalloJosé A Dávila
Nov 1, 1994·Developmental and Comparative Immunology·J A MarshC G Scanes
Aug 13, 2004·Proceedings. Biological Sciences·Barbara TschirrenHubert Schwabl
May 1, 1993·Journal of Endocrinological Investigation·L ChiovatoA Pinchera
Jan 24, 2014·Ecology and Evolution·Sveinn Are HanssenKjell Einar Erikstad
Jun 12, 2019·Journal of Clinical Pharmacy and Therapeutics·Robert KrysiakBogusław Okopień
Sep 15, 2019·Journal of Clinical Pharmacy and Therapeutics·Robert KrysiakBogusław Okopień
Oct 31, 2020·Diagnostics·Cristina Mihaela CepehaDana Stoian

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