PMID: 2508757Oct 13, 1989Paper

Effect of tetrachlorodibenzo-p-dioxin (TCDD) on the glucuronidation of retinoic acid in the rat

Biochimica Et Biophysica Acta
P A BankM H Zile

Abstract

Administration of a single oral dose (10 micrograms/kg) of tetrachlorodibenzo-p-dioxin (TCDD) caused a 33% decrease in retinyl esters in the livers of male rats, but a 13-fold increase in retinyl esters in the kidney and a 3-fold increase in serum retinol. Liver and kidney microsomal uridine diphosphoglucuronosyltransferase (UDPGT) activity toward all-trans-retinoic acid was increased 3.7- and 2.6-fold, respectively, ten days following exposure to TCDD. Verification of the in vitro formation of [3H]retinoyl beta-glucuronide (RG) was by cochromatography with authenic RG on reversed phase high pressure liquid chromatography (HPLC), identification of retinoic acid as the hydrolysis product after beta-glucuronidase treatment, and the characterization of the all-trans-retinoyl glucuronide by negative fragment mass spectroscopy, fast atom bobardment. We conclude that increased retinoic acid glucuronidation may be a contributing factor to the hepatic depletion of vitamin A and the increased excretion of vitamin A metabolites following TCDD exposure.

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Citations

Feb 28, 2003·Chemico-biological Interactions·Pi HoegbergHelen Håkansson
Mar 11, 2000·Drug and Chemical Toxicology·M C Kohn
May 9, 2014·Integrative and Comparative Biology·Mathieu Giraudeau, Kevin J McGraw
Jun 20, 2002·Critical Reviews in Toxicology·Charlotte B Nilsson, Helen Håkansson
Feb 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Noriko NishimuraChiharu Tohyama
Sep 15, 1995·Journal of Chromatography. B, Biomedical Applications·R Wyss

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