PMID: 6159013Oct 1, 1980Paper

Effect of tetrodotoxin and ethmozine on arrhythmias of a dog heart isolated in the late stage of experimental myocardial infarct

Biulleten' eksperimental'noĭ biologii i meditsiny
L V RozenshtraukhS A Dremin

Abstract

Dog hearts with ventricular extrasystole that developed 24 hours after coronary artery occlusion were isolated and perfused with blood from support dogs. After heart isolation the rhythm disturbances persisted regardless the decreased frequency of the ventricular beats. Administration of tetrodotoxin (4 X 10-8--10-7 g/ml) and ethmozine (3--5X X10-5 g/ml) abolished ventricular arrhythmias and restored the sinus rhythm. Potential mechanisms of the increased susceptibility of ischemic myocardial fibers to tetrodotoxin and antiarrhythmic drugs are discussed.

References

Jun 1, 1979·Cardiovascular Research·R RuffyD P Zipes
May 1, 1978·The American Journal of Cardiology·R LazzaraB J Scherlag
Jul 1, 1977·Clinical Science and Molecular Medicine·J J PhelanC F McCarthy
Jan 1, 1967·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·J DudelW Trautwein

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Citations

Jul 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·G P Ul'ianov
Oct 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·A I UndrovinasA V Iushmanova
Jan 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·L V RozenshtraukhG G Beloshapko
May 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·B SchubertA Wollenberger
Nov 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·E I NazarovV G Vongaĭ

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