Effect of Th1 cytokines on acid secretion in pharmacologically characterised mouse gastric glands

Gut
I T Padol, R H Hunt

Abstract

Acid secretion plays an important role in the ecology of Helicobacter species and acid secretory status heralds patterns of gastritis. The presence of inflammatory cells and their products, in close proximity to parietal cells, questions the extent of the effect of cytokines on acid secretion. We adopted and extensively characterised the mouse gastric gland preparation and its secretory capacity, which was measured using (14)C-aminopyrine accumulation. Subsequently, we tested the secretory properties of a wide range of species specific cytokines, including those associated with Th1 and Th2 immune responses. (14)C-aminopyrine accumulation in mouse gastric glands was shown to be a very sensitive "in vitro" method of testing classical secretagogues and antisecretory compounds, and provided pharmacological data on acid secretion in the mouse. Only two mouse cytokines, interleukin 2 and interferon gamma, had a direct effect on acid secretion causing dose dependent inhibition. Both cytokines belong to the Th1 type immune response and consequently their inhibitory effect may play a role in the hyposecretion seen with H pylori infection and colonisation throughout the corpus of the stomach that potentially can lead to gastric atrophy a...Continue Reading

References

Aug 15, 1989·Biochemical and Biophysical Research Communications·A UeharaM Namiki
Jun 1, 1988·Biochemical Pharmacology·D J KeelingJ Senn-Bilfinger
Oct 13, 2000·Gastroenterology Clinics of North America·K E McCollD Gillen
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Karen L HinkleLinda C Samuelson

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Citations

Aug 9, 2008·Japanese Journal of Clinical Oncology·Rajeev MahajanLifang Hou
Sep 3, 2008·Journal of Gastroenterology and Hepatology·Woon Geon ShinHak Yang Kim
Nov 28, 2007·Annual Review of Pathology·John C Atherton
Sep 17, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·P B ErnstK S Tung
Mar 12, 2010·World Journal of Gastroenterology : WJG·Mitsushige SugimotoTakahisa Furuta
Apr 6, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shi-Qi FangXiu-Min Lu
Nov 16, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I T PadolR H Hunt
Jan 28, 2006·FEMS Microbiology Reviews·Karin van AmsterdamArie van der Ende
Jan 29, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ireneusz T Padol, Richard H Hunt
Nov 2, 2019·Physiological Reviews·Amy C EngevikJames R Goldenring

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