Effect of the antimicrobial peptide tritrpticin on the in vitro viability and growth of Trichomonas vaginalis.

Current Microbiology
Veronica V InfanteEva E Avila

Abstract

Antimicrobial peptides are widely distributed in nature; they play important roles in several aspects of innate immunity and may provide a basis for the design of novel therapeutic agents. In this study, C-amidated tritrpticin, a 13 amino acid tryptophan-rich antimicrobial peptide derived from a porcine cathelicidin, was tested against Trichomonas vaginalis, a protozoan that causes a serious non-viral sexually transmitted disease associated with preterm birth, low birth weight, and high risk of HIV-1 infection. Tritrpticin was selected due to its reasonably easy synthesis and because analogs with lower toxicity may be designed. Our results show that tritrpticin-NH(2) at either 100 or 200 μg/ml (52.5 or 105 μM) clearly reduces the viability and growth of Trichomonas vaginalis. Together with tritrpticin-NH(2), sodium bicarbonate further limited trichomonad growth. Additionally, a low concentration of metronidazole (5.8 μM), the most commonly used medication for Trichomonas vaginalis, was more effective against the growth of the parasite when it was combined with tritrpticin-NH(2).

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Citations

Dec 27, 2015·Experimental Parasitology·Mariana DuarteAlexandre José Macedo
Jan 11, 2016·World Journal of Microbiology & Biotechnology·Nadin ShagaghiMrinal Bhave
Aug 15, 2015·Human Nature : an Interdisciplinary Biosocial Perspective·Caroline DoylePaul W Ewald
Mar 31, 2015·BioMed Research International·J L Hernandez-FloresE E Avila
Apr 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Awdhesh Kumar MishraKwang-Hyun Baek
Aug 1, 2020·Frontiers in Cellular and Infection Microbiology·Derry K MercerAlfredo M Angeles-Boza

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