Effect of the anxiolytic drug buspirone on prolactin and corticosterone secretion in stressed and unstressed rats

Pharmacology, Biochemistry, and Behavior
J H UrbanC L Bethea

Abstract

Buspirone is an atypical anxiolytic drug that exerts its action at a receptor site other than the GABA-benzodiazepine-chloride ionophore complex. The present study examined the effect of buspirone on plasma prolactin and corticosterone levels in both control and stressed rats. In unstressed rats, buspirone produced dose-dependent increases in plasma prolactin and corticosterone levels. The minimal doses of buspirone which led to significant elevations in plasma prolactin and corticosterone levels were 1.0 and 2.0 mg/kg (IP), respectively. The effect of buspirone on both hormones was maximal 30 minutes after injection. The plasma levels of prolactin and corticosterone were significantly elevated in rats that were stressed using a conditioned fear paradigm. Buspirone produced a dose-dependent attenuation of the stress-induced increase in prolactin secretion. The stress-induced increase in corticosterone secretion was inhibited by the 0.5 mg/kg (IP) dose but not by the 2.0 mg/kg (IP) dose of buspirone, which increased corticosterone secretion both in stressed and unstressed rats. These data suggest that the effect of buspirone on plasma prolactin and corticosterone levels may be mediated by two different mechanisms of action.

References

Jan 1, 1991·Journal of Neural Transmission. General Section·E PrzegalinskiA Grochmal
Jan 21, 1992·European Journal of Pharmacology·K S Panickar, Neil McNaughton
Apr 1, 1988·Pharmacology, Biochemistry, and Behavior·J I KoenigG A Gudelsky
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·K S Panickar, Neil McNaughton
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·M Freire-GarabalM Rey-Mendez
May 1, 1996·Pharmacology, Biochemistry, and Behavior·L GroeninkB Olivier
Jan 1, 1993·Brain Research. Brain Research Reviews·F Chaouloff
Jan 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·J AkiyoshiH Nagayama
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, L D Van de Kar
Feb 26, 2003·European Journal of Pharmacology·B OlivierL Groenink
Oct 1, 1996·Pharmacology, Biochemistry, and Behavior·L GroeninkB Olivier
Aug 26, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·G PalitB N Dhawan
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·L D Van de Kar
Mar 25, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H MattssonA Lehmann
Jan 12, 1999·Frontiers in Neuroendocrinology·L D Van de Kar, M L Blair
May 18, 2016·Pharmacology, Biochemistry, and Behavior·Susan M TyreeNeil McNaughton
Jan 27, 2019·Psychiatric Genetics·Kayla BalajChristopher J Keary
Jul 11, 2008·Critical Reviews in Toxicology·Edward J Calabrese

Citations

Jul 1, 1977·Steroids·H P MathieuC Vrignaud
Apr 1, 1985·Biopharmaceutics & Drug Disposition·R E GammansL F Sokya
Oct 1, 1985·Pharmacology, Biochemistry, and Behavior·D P TaylorC P VanderMaelen
Jan 1, 1985·Psychopharmacology·D JezováF Labrie
May 1, 1982·The Journal of Pharmacy and Pharmacology·K KolasaH Ladinsky
Mar 18, 1983·European Journal of Pharmacology·T Glaser, J Traber
Jul 18, 1983·Life Sciences·P L WoodP Etienne
Jan 1, 1983·Journal of Neural Transmission·M K Sanghera, D C German
Jan 1, 1984·Psychopathology·L A RibletC P VanderMaelen
Oct 8, 1984·Brain Research·L D Van de KarC L Bethea
Jan 1, 1982·Annual Review of Pharmacology and Toxicology·R W Olsen
Mar 1, 1984·The International Journal of Neuroscience·J S Richardson
Aug 1, 1980·Neuroendocrinology·R W Fuller, H D Snoddy
Oct 30, 1984·European Journal of Pharmacology·M E Trulson, L J Henderson
Jan 1, 1982·Neuroendocrinology·L Grandison

Related Concepts

Corticosterone Assay
Corticosterone Secretion
Exertion
August Rats
Mental Suffering
Benzodiazepine [EPC]
PRL gene
Pituitary Gland, Anterior
Ionophores
Prolactin Measurement

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.