Effect of the appetite stimulant cyproheptadine on deoxynivalenol-induced reductions in feed consumption and weight gain in the mouse

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
D B PreluskyH L Trenholm

Abstract

Deoxynivalenol (DON, vomitoxin), a Fusarium mycotoxin, is suspected of inducing its anorectic/feed refusal activity through a serotoninergic (5HT) mechanism, possible via 5HT2-receptors. In this study the efficiency of cyproheptadine (CYP), a serotonin antagonist and known appetite stimulant, to attenuate the adverse effect of DON was investigated in mice. CYP was administered in the feed for two days before animals began receiving the DON, which was also added to the feed. Both agents were administered concurrently thereafter for a 12-day period. Dosing levels included various combinations of the two compounds, ranging from 0-16 ppm DON and 0-20 ppm CYP.

Citations

Apr 5, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·S J HepworthP C Turner
Jul 25, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chidozie J AmuzieJames J Pestka
Oct 7, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chidozie J Amuzie, James J Pestka
Feb 6, 2013·Analytical and Bioanalytical Chemistry·Yanshen LiSuxia Zhang
Mar 17, 2004·Eating and Weight Disorders : EWD·J M Mancilla-DíazV E López-Alonso
Feb 24, 2001·Journal of Food Protection·F GalvanoG Galvano

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