Effect of the Arctic terrestrial plant Ranunculus hyperboreus on LPS-induced inflammatory response via MAPK pathways

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
Chang-Suk KongYoungwan Seo

Abstract

The Arctic flora hosts a limited number of species due to its extreme environmental conditions which also yield novel and unique secondary metabolites from withstanding plants. Considering a lack of research on bioactivity potential of Arctic flora, Ranunculus hyperboreus, an Arctic plant, was studied for its anti-inflammatory potential as a part of ongoing research on discovering novel natural bioactive products. Solvent-based fractions (H2O, n-BuOH, 85% aq. MeOH, n-hexane) from R. hyperboreus extract were observed to decrease the elevated nitrate amount during the inflammatory response of lipopolysaccharide-induced mouse macrophage RAW264.7 cells. To some extent, treatment with fractions was able to regulate the expression and protein levels of inflammation-related enzymes, iNOS and COX-2, and pro-inflammatory cytokines, TNF-α, IL-1β, and IL-6. The most active fractions, H2O and 85% aq. MeOH, were suggested to exert their effect through suppressed activation of MAPK pathways, especially JNK. Based on the studies of same species, phenolic glycosides were suggested to be the main active ingredients. To our knowledge, this is the first report of any bioactivity of R. hyperboreus which could be a valuable source of natural bioact...Continue Reading

References

Sep 28, 1999·Molecular Medicine Today·E Herlaar, Z Brown
Sep 1, 2000·Journal of Ethnopharmacology·D MantleA T Pickering
Jun 16, 2005·Molecular Phylogenetics and Evolution·Elvira HörandlPeter Lockhart
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hanne Hegre GrundtChristian Brochmann
Oct 28, 2009·Journal of Ethnobiology and Ethnomedicine·Maria Lucia Leporatti, Kamel Ghedira
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Apr 28, 2011·Applied Microbiology and Biotechnology·Amal Hassan AlyPeter Proksch
Jul 24, 2013·Inflammation & Allergy Drug Targets·Durgaprasad LavetiRavinder Nagpal

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here