PMID: 3319645Jan 1, 1987Paper

Effect of the calcium antagonist nilvadipine on haemodynamics at rest and during cold stimulation in essential hypertension

European Journal of Clinical Pharmacology
T TakabatakeN Hattori

Abstract

The immediate haemodynamic effects of the calcium antagonist nilvadipine have been studied in ten patients with established mild essential hypertension. Nilvadipine 4 mg p.o. reduced both the systolic and diastolic blood pressures within 60 min, associated with a fall in total peripheral resistance and an increase in heart rate and cardiac index. The peak of blood pressure and total peripheral resistance reached during a cold pressor test were reduced by nilvadipine, but it did not affect the haemodynamic responsiveness to cold stimulation. Plasma renin activity was unaltered and the plasma noradrenaline concentration was increased only slightly. Thus, nilvadipine lowered blood pressure at rest and during cold stimulation as a result of arteriolar dilatation. The hypotensive effect at rest was associated with a reflex increase in heart rate and cardiac index.

References

May 21, 1979·European Journal of Clinical Pharmacology·O L PedersenE B Pedersen
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·T TakabatakeN Hattori
Nov 1, 1965·The Journal of Physiology·J H Burn, W R Gibbons
Jul 1, 1980·Journal of Cardiovascular Pharmacology·O Lederballe PedersenK D Rämsch
Nov 1, 1983·Journal of Cardiovascular Pharmacology·M OhtsukaS Kumada
Dec 23, 1982·The New England Journal of Medicine·E Braunwald
Jan 1, 1983·European Journal of Clinical Pharmacology·K AokiM Yamamoto
Jan 1, 1983·Postgraduate Medical Journal·W A LittlerR A McLeay

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