Effect of the calcium channel blockers nifedipine and diltiazem on pentylenetetrazole kindling-provoked amnesia in rats

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
M Genkova-PapazovaM Lazarova-Bakarova

Abstract

A large body of research supports the view that memory disturbance is an integral part of epilepsy. Deficit in various behaviour tasks has been found in rats subjected to experimental epilepsy-pentylenetetrazole (PTZ) kindling. In the present study we examined the effect of post-training administered calcium channel blockers nifedipine (10 and 40 mg/kg) and diltiazem (10 and 30 mg/kg) on amnesia induced by PTZ kindling in shuttle-box- and step-down-trained rats. Retention in nifedipine- or diltiazem-treated kindled animals was significantly improved compared to the kindled controls. The mechanisms of action of calcium antagonists studied is considered. Taken together with the data about calcium channel blocker anticonvulsive activity, the results of this study further suggest that nifedipine and diltiazem might be useful in the treatment of cognitive disorders in epileptic patients.

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Citations

Aug 13, 2005·Experimental Brain Research·Axel BeckerGisela Grecksch
Jul 6, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Anu RaniAmanpreet Kaur
Jun 21, 2014·Pharmacological Reports : PR·Kinga K Borowicz, Monika Banach
Nov 6, 2010·Journal of the Association for Research in Otolaryngology : JARO·Bruce MockSherri M Jones

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