Effect of the combination of alinidine and other anti-anginal drugs on heart rate and blood pressure in healthy volunteers

British Journal of Clinical Pharmacology
D W HarronR G Shanks

Abstract

1. Heart rate and blood pressure changes following the administration of alinidine 30 mg alone and in combination with atenolol 25 mg, nifedipine retard 20 mg and glyceryl trinitrate 500 micrograms were investigated in three groups of six healthy male volunteers. 2. Concomitant administration of alinidine and atenolol reduced (P less than 0.05) supine, standing and exercise heart rate when compared with alinidine alone. The maximum reduction in exercise heart rate was 116 +/- 2.4 beats min-1 for the combination vs 129.0 +/- 3.1 beats min-1 for alinidine alone. 3. Supine (3, 4, 8 h) and standing (2 h) systolic BP were also reduced (P less than 0.05) with the alinidine and atenolol combination compared with alinidine alone. Little change occurred in diastolic blood pressure. 4. Alinidine and nifedipine in combination reduced (P less than 0.05) the nifedipine induced increase in heart rate in the supine (2, 4 h) and standing (4 h) position and following exercise (2, 4 h). No further decreases in systolic and diastolic blood pressure occurred with the combination. 5. Alinidine administered 2 h before a glyceryl trinitrate challenge reduced (P less than 0.05) the glyceryl trinitrate induced increase in standing heart rate at all tim...Continue Reading

References

Apr 30, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·W KobingerL Pichler
Sep 15, 1979·European Journal of Pharmacology·W KobingerL Pichler
Jan 1, 1982·European Journal of Clinical Pharmacology·J SchurmansH De Geest
Dec 1, 1982·European Heart Journal·M L SimoonsR van Domburg
Jan 1, 1982·European Journal of Clinical Pharmacology·J AuböckE Olbrich

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