Effect of the disease severity on the risk of developing new-onset diabetes after acute pancreatitis

Medicine
Jianfeng TuJieshou Li

Abstract

Endocrine pancreatic insufficiency secondary to acute pancreatitis (AP) drew increasing attention in the recent years. The aim of the present study was to assess the impact of pancreatic necrosis and organ failure on the risk of developing new-onset diabetes after AP.The follow-up study was conducted for patients recovered from AP in the treatment center of Jinling Hospital. Endocrine function was evaluated by simplified oral glucose tolerance test (OGTT). Pancreatic necrosis was examined by abdominal contrast-enhanced CT (CECT) scan during hospitalization. The data including APACHE II score, Balthazar's score, organ failure (AKI and ARDS) was also collected from the medical record database. All patients were divided into group diabetes mellitus (DM) and group non-DM according to the endocrine function and group pancreatic necrosis (PN) and persistent organ failure (OF), group PN and non-OF, group non-PN and OF, and group non-PN and non-OF according to the occurrence of pancreatic necrosis and persistent organ failure.Around 256 patients were included for the final analysis. 154 patients (60.2%) were diagnosed with DM (include impaired glucose tolerance, IGT), while 102 patients (39.8%) were deemed as normal endocrine function....Continue Reading

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Citations

Nov 16, 2018·European Journal of Gastroenterology & Hepatology·Ji-Hong MaJing-Ye Pan
May 7, 2019·Journal of Pediatric Gastroenterology and Nutrition·Zaheer NabiDuvuur Nageshwar Reddy
Nov 6, 2020·The Korean Journal of Internal Medicine·Allyson Richardson, Walter G Park
May 22, 2021·Pancreas·Stephen A FirkinsSomashekar G Krishna
May 18, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yaling YiAliye Uc
Nov 15, 2019·Journal of Agricultural and Food Chemistry·Jinlong GaoDuo Li

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Methods Mentioned

BETA
pancreatectomy

Software Mentioned

SPSS

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