PMID: 9165446May 1, 1997Paper

Effect of the environment on fetal skin wound healing

Journal of Pediatric Surgery
M A SanchoL Morales

Abstract

Skin wound healing has been shown to be a different process in the fetus than in the adult animal. Some of these differences have been attributed to the unique fetal environment (i.e., amniotic fluid). The aim of the present study is to compare fetal skin healing in intraamniotic and extraamniotic wounds. A fetal rabbit model has been used in which three types of skin wounds were induced on 23-day-old fetuses in contact with either amniotic fluid or maternal peritoneal fluid. The wounds consisted of a sutured skin incision, a nonsutured incision, and an electrocautery burn. Seven days later all wounds were examined mechanically (scar resistance), biochemically (collagen and noncollagen protein concentration), and histologically. Biochemical and growth factor studies of both environments, the amniotic and the peritoneal fluids, were also conducted. The results showed excellent healing by first intention and absence of healing by second intention in both environments, greater scar resistance in the intraperitoneally positioned fetal wounds, and a higher concentration of insulin-like growth factor-1 (IGF-1) in the peritoneal fluid than in the amniotic fluid. It can be concluded that fetal skin wounds in contact with peritoneal flu...Continue Reading

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Citations

Aug 24, 1999·Plastic and Reconstructive Surgery·J P BarretD N Herndon
Oct 11, 2001·The Journal of Surgical Research·H LevinsonH P Ehrlich
Jun 29, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Aleksander SkardalShay Soker
Mar 27, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Halil Ibrahim AltinsoyS Ümit Sarici
Jun 18, 2002·Annals of Plastic Surgery·Victoria JuliáLuís Morales
May 29, 2004·The Journal of Craniofacial Surgery·Fatih UygurMustafa Sengezer
Apr 17, 2007·Current Opinion in Ophthalmology·Polly A Quiram, Antonio Capone
Sep 3, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P A Hebda, J E Dohar

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