Effect of the ethinylestradiol/norelgestromin contraceptive patch on body composition. Results of bioelectrical impedance analysis in a population of Italian women.

Nutrition Journal
Antonio PiccoliItalian EVRA Contrast Study Group

Abstract

As weight gain is one of the most frequently cited reasons for not using and for discontinuing hormonal contraceptives, in an open-label, single-arm, multicentre clinical study we evaluated the effect of the ethinylestradiol/norelgestromin contraceptive patch (EVRA, Janssen-Cilag International, Belgium) on body composition using bioelectrical impedance analysis (BIA). Body weight and impedance vector components (resistance (R) and reactance (Xc), at 50 kHz frequency, Akern-RJL Systems analyzer) were recorded before entry, after 1, 3 and 6 months in 182 Italian healthy women aged 29 yr (18 to 45), and with BMI 21.8 kg/m2 (16 to 31). Total body water (TBW) was estimated with a BIA regression equation. Vector BIA was performed with the RXc mean graph method and the Hotelling's T2 test for paired and unpaired data. After 6 months body weight increased by 0.64 kg (1.1%) and TBW increased by 0.51 L (1.7%). The pattern of impedance vector displacement indicated a small increase in soft tissue hydration (interstitial gel fluid). Body composition changes did not significantly differ among groups of previous contraceptive methods. Arterial blood pressure did not significantly change over time. After 6 months of treatment with the ethinyl...Continue Reading

References

May 1, 1995·The Journal of Reproductive Medicine·M J RosenbergS Long
Mar 21, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A PiccoliF Cavagnini
Jan 15, 2004·Contraception·Laura M GaudetRobert L Reid
Feb 12, 2004·Kidney International·Antonio Piccoli, UNKNOWN Italian CAPD-BIA Study Group
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ursula G KyleUNKNOWN Composition of the ESPEN Working Group
May 7, 2005·Contributions to Nephrology·Antonio Piccoli
Jun 4, 2005·Obstetrics and Gynecology·Felicia H StewartAndrew J Friedman
Jan 27, 2006·The Cochrane Database of Systematic Reviews·M F GalloF M Helmerhorst
Mar 15, 2006·Contraception·Rogério Bonassi MachadoEdna Maia
Jan 16, 2007·The British Journal of Nutrition·Antonio PiccoliAntonio Paoli
Aug 11, 2007·American Journal of Obstetrics and Gynecology·Ronald T Burkman
Sep 25, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Stefano LelloGian Benedetto Melis

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Citations

Aug 11, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Johan Verhaeghe
Feb 18, 2017·Frontiers in Cardiovascular Medicine·Mika EnomotoYoshihiro Fukumoto

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Methods Mentioned

BETA
method
of
contraception

Software Mentioned

Vector BIA
BIVA

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