Effect of the glial envelope on extracellular K(+) diffusion in olfactory glomeruli

Journal of Neurophysiology
Anita R GorielyLeslie P Tolbert

Abstract

In many species, including vertebrates and invertebrates, first-order olfactory neuropils are organized into spherical glomeruli, partially enveloped by glial borders. The effect of this characteristic organization on olfactory information processing is poorly understood. The extracellular concentration of potassium ions ([K(+)]) must rise around olfactory receptor axons in specific glomeruli following odor-induced activation. To explore the time course and magnitude of K(+) accumulation and possible effects of such accumulation on neural activity within and among glomeruli, we developed a theoretical model to simulate the diffusion of K(+) in extracellular spaces of the glomeruli of the moth Manduca sexta. K(+) released by activated axons was assumed to diffuse through the extracellular spaces in glomeruli and the glial borders that surround them. The time-dependent diffusion equations were solved in spherical coordinates using a finite-difference method. The results indicate that the glial envelope forms a significant barrier to the spread of K(+) between neighboring glomeruli, thus reducing the likelihood of cross-talk between glomeruli, and may cause elevation of extracellular [K(+)] to levels that influence neural activity...Continue Reading

References

Sep 29, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·H KornD S Faber
Nov 1, 1992·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·F Marion-Poll, T R Tobin
May 22, 1991·The Journal of Comparative Neurology·F Valverde, L Lopez-Mascaraque
Aug 10, 1990·Science·C J McBainR Dingledine
Jan 1, 1987·The Journal of Physiology·K BallanyiG ten Bruggencate
Oct 31, 1988·Neuroscience Letters·A KhayariJ L Davrainville
Jan 1, 1986·Annals of the New York Academy of Sciences·A R Gardner-Medwin
Dec 1, 1973·The Journal of Comparative Neurology·T J Willey
Jul 1, 1966·Journal of Neurophysiology·S W KufflerR K Orkand
Sep 1, 1981·The Journal of Physiology·C E Jahr, R A Nicoll
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·L L LatourC H Sotak
Apr 1, 1996·Chemical Senses·K E Kaissling
May 1, 1996·Journal of Neurobiology·T A ChristensenJ G Hildebrand
Nov 15, 1996·Cell·P MombaertsR Axel
Jan 1, 1997·Annual Review of Neuroscience·J G Hildebrand, G M Shepherd
Sep 23, 1997·Glia·T AmédéeJ A Coles
Jun 4, 1998·Trends in Neurosciences·C Nicholson, E Syková
Apr 23, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A BacciM Matteoli
Jun 17, 1999·Trends in Neurosciences·G T Buracas, T D Albright
Aug 25, 1999·Cell and Tissue Research·L A OlandI Burger
Aug 16, 2000·Cell·L B VosshallR Axel
Feb 22, 2001·Annual Review of Physiology·D A McCormick, D Contreras
Jan 1, 1963·Journal of Neurophysiology·T FURUKAWA, E J FURSHPAN

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Citations

Jul 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chad CollmannAlan Nighorn
Oct 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lisa RouxChristian Giaume
Jun 10, 2008·The Journal of Comparative Neurology·Lynne A OlandLeslie P Tolbert
Oct 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Keith K Murai, Donald J Van Meyel

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