Effect of the gln-1b mutation on nitrogen metabolite repression in Neurospora crassa.

Journal of Bacteriology
N S Dunn-Coleman, R H Garrett

Abstract

In Neurospora crassa, synthesis of the enzymes of nitrate assimilation, nitrate reductase and nitrite reductase, was repressed by the presence of ammonium, glutamate, or glutamine. This phenomenon was a manifestation of the regulatory process termed nitrogen metabolite repression whereby alternative pathways of nitrogen acquisition are not expressed in cells enjoying nitrogen sufficiency. However, the glutamine synthetase mutant gln-1b had derepressed levels of the nitrate assimilation enzymes. The inability of glutamine to achieve nitrogen metabolite repression in this mutant militated against its potential role as the direct effector of this regulation.

References

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Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·R H Garrett, A Nason
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