PMID: 11311501Apr 20, 2001Paper

Effect of the glycine modulatory site of the N-methyl-D-aspartate receptor on synaptic responses in kitten visual cortex

Neuroscience Letters
K Ito, T P Hicks

Abstract

In visual cortical slices taken from kittens, the administration of D-serine, an agonist of the N-methyl-D-aspartate receptor complex, significantly enhanced synaptically evoked responses using field potential recordings in lower layer II/III. Expression of normally appearing long-term potentiation (LTP) took place in the presence of the agonist during high-frequency stimulation (HFS). The administration of an antagonist of this receptor, 7-chloro-kynurenic acid (7-Cl KY) alone had no appreciable effect on low-frequency synaptic transmission while HFS failed to induce LTP. Combined administration of D-serine and 7-Cl KY resulted in no alteration of low-frequency synaptic transmission, although expression of LTP was normally obtained. These results suggest that in visual cortex of kittens, the availability of this glycine binding site of the NMDA receptor is necessary for the expression of LTP.

References

Jan 13, 1992·FEBS Letters·A HashimotoK Takahashi
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J A KempG N Woodruff
Jan 1, 1994·Experimental Brain Research·K I Ito, T P Hicks

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Citations

Aug 14, 2012·Amino Acids·Jean-Marie Billard
Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Judit FüvesiJózsef Toldi
Sep 30, 2009·Molecular Psychiatry·L VerrallP J Harrison
Jul 22, 2010·The Open Medicinal Chemistry Journal·Sean M SmithPeter H Hutson
Jun 2, 2005·The European Journal of Neuroscience·N V KrasteniakovR Bergeron
Sep 21, 2007·The European Journal of Neuroscience·Louise VerrallPhilip W J Burnet

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