Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice

The Journal of Nutritional Biochemistry
Timothy R KochEmmanuel C Opara

Abstract

Antioxidant depletion is believed to be a mechanism involved in the pathophysiology of several upper gastrointestinal disorders, and H, K-ATPase inhibitors can alter free radical production by neutrophils. We hypothesized that the H, K-ATPase inhibitor esomeprazole magnesium would decrease gut free radical production with a concomitant increase in gut total antioxidant capacity. A/J mice (n = 10/group) received either vehicle (control) or one of three concentrations of esomeprazole magnesium in vehicle by once-daily gavage for 10 days. Using tissue extracts from stomach and colon, total antioxidant capacity, lipid peroxide levels, and constitutive Cu/Zn-superoxide dismutase were measured using validated assays. There was a dose-related increase in total antioxidant capacity (analysis of variance, P < 0.001) in stomach, but there was no change in the colon. In the assessment of free radical production, there was a trend toward decreased lipid peroxide levels in stomach from mice receiving esomeprazole. In stomach, Cu/Zn-superoxide dismutase activity was increased (ANOVA: p=.03) in mice receiving esomeprazole. In conclusion, gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity are increased by esomeprazole, ...Continue Reading

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J MårtenssonA Meister
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·E CarlssonG Sundell
Mar 11, 1996·FEBS Letters·D LapennaF Cuccurullo
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May 1, 2001·Journal of Clinical Pathology·I S Young
Dec 6, 2001·European Journal of Pharmacology·S CuzzocreaD Salvemini

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Citations

Feb 17, 2005·Digestive Diseases and Sciences·Timothy R KochEmmanuel C Opara
Aug 29, 2009·Digestive Diseases and Sciences·Ramalinga R KedikaStuart Jon Spechler
Aug 27, 2013·European Journal of Pharmacology·Kun LinZhaoliang Shan
Aug 6, 2008·European Journal of Gastroenterology & Hepatology·Kristin G NørsettArne K Sandvik

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