Effect of the H1 -antihistamine clemastine on PACAP38 induced migraine

Cephalalgia : an International Journal of Headache
Luise Haulund VollesenMessoud Ashina

Abstract

To investigate the effect of the H1-antihistamine clemastine on the migraine-inducing abilities of pituitary adenylate cyclase activating peptide-38. We conducted a double-blind, randomized, placebo controlled two-way cross-over study. Twenty migraine without aura patients were randomly allocated to receive bolus clemastine 2 mg (1 mg/ml) or bolus saline 2 ml intravenously over 2 min on two study days. Following each bolus injection, 10 pmol/kg/min of pituitary adenylate cyclase activating peptide-38 was administered intravenously over 20 min. We recorded migraine/headache characteristics every 10 min until 90 min after the start of infusion, and collected blood to investigate mast cell degranulation and the inflammation markers tryptase and tumor necrosis factor-alpha before and after infusion of pituitary adenylate cyclase activating peptide-38. After clemastine pretreatment, five out of 20 participants developed a migraine-like attack in response to a pituitary adenylate cyclase activating peptide-38 infusion compared to nine out of 20 after placebo pretreatment ( p = 0.288). Following clemastine pretreatment, 15 out of 20 participants reported headache in response to a pituitary adenylate cyclase activating peptide-38 infus...Continue Reading

References

May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L J WalshG F Murphy
Mar 1, 1982·Clinical Allergy·R V HeatleyJ Bienenstock
Sep 1, 1997·Methods : a Companion to Methods in Enzymology·A D Hogan, L B Schwartz
Jan 19, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L OdumL B Ebskov
Jul 21, 1999·Journal of the Autonomic Nervous System·J TajtiL Edvinsson
Jun 18, 2005·Brain Research. Brain Research Reviews·Theoharis C TheoharidesAphrodite Konstantinidou
Feb 8, 2008·Cephalalgia : an International Journal of Headache·A RahmannM Ashina
Dec 5, 2008·Brain : a Journal of Neurology·Henrik Winther SchytzMessoud Ashina
Jul 21, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P Tfelt-HansenJ Olesen
May 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Henrik W SchytzMessoud Ashina
May 11, 2010·The Journal of Headache and Pain·Henrik Winther SchytzMessoud Ashina
Dec 17, 2011·Cephalalgia : an International Journal of Headache·Faisal Mohammad AminMessoud Ashina
Mar 17, 2012·Cephalalgia : an International Journal of Headache·Michael BaunInger Jansen-Olesen
Jan 18, 2014·Headache·Karl B Alstadhaug
Feb 25, 2014·Cephalalgia : an International Journal of Headache·Deepak K BhattInger Jansen-Olesen
Mar 20, 2016·Cephalalgia : an International Journal of Headache·Song GuoMessoud Ashina
Apr 17, 2016·Cephalalgia : an International Journal of Headache·Anne Luise Haulund VollesenMessoud Ashina

❮ Previous
Next ❯

Citations

Jul 14, 2019·Cephalalgia : an International Journal of Headache·Hashmat GhanizadaMessoud Ashina
Jan 17, 2020·Headache·Katrine FalkenbergJes Olesen
Feb 12, 2021·Cephalalgia : an International Journal of Headache·Nita Katarina Frifelt WienholtzMessoud Ashina
Jan 19, 2022·Headache·Ada R ArtemenkoAlexey B Danilov

❮ Previous
Next ❯

Methods Mentioned

BETA
pregnancy tests

Clinical Trials Mentioned

NCT02364453

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.