Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (review)

Molecular Medicine Reports
Jue Jiang, Hong Jiang

Abstract

The incidence of Alzheimer's disease (AD) in individuals >65 years of age is 13% and ~66 million individuals in this age group undergo surgery annually under anesthesia. It is therefore important to determine whether commonly used inhaled anesthetics induce cytotoxicity, which may lead to neurodegeneration. Findings from several studies suggest that the anesthetics, isoflurane, sevoflurane and desflurane, may activate caspases, increase the synthesis and accumulation of β-amyloid (Aβ) protein, and induce hyperphosphorylation of tau proteins, all of which are cellular responses consistent with the neuropathogenesis of AD. Other studies have arrived at different and occasionally contradictory conclusions. The present review attempts to resolve this discrepancy by reviewing previous studies, which have investigated the effects of commonly used inhaled anesthetics on the synthesis and accumulation of Aβ, tau pathology and cognitive function. The possible underlying mechanism was also reviewed. However, several aspects of this phenomenon remain to be elucidated. Further studies are required to fully examine anesthesia-induced neurotoxicity and elucidate the effect of inhaled anesthetics on the onset and progression of AD.

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Citations

Feb 6, 2018·Chembiochem : a European Journal of Chemical Biology·Ferenc Zsila
Feb 23, 2019·Journal of Anesthesia·Shinichi NakaoTatsushige Iwamoto
May 8, 2018·Journal of Neurosurgical Anesthesiology·Andrew LigsayRandi Hagerman
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Apr 5, 2018·Journal of Alzheimer's Disease : JAD·Clara Tammy KimDoh Kwan Kim
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Jan 6, 2019·Nature Reviews. Neurology·Francesco PanzaBruno P Imbimbo
Jun 27, 2019·Journal of Neurophysiology·Fahad IqbalNaweed I Syed
Mar 24, 2021·Biochemical and Biophysical Research Communications·Qingcai ChenXin Jin
Nov 22, 2017·British Journal of Anaesthesia·M J NeedhamD C Bryden

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Methods Mentioned

BETA
transgenic

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