Effect of the intravenous lipid emulsions on the availability of calcium when using organic phosphate in TPN admixtures.

Pharmaceutical Research
Sonia Chaieb DSouad Sfar

Abstract

The addition of high amounts of calcium remains a pharmaceutical concern due to its precipitation with phosphate in total parenteral nutrient (TPN) admixtures, compromising also the stability of the lipid emulsion. Calcium-phosphate solubility was compared when using binary PN solutions versus all-in-one TPN (admixtures with lipid emulsions) in three formulas using organic calcium gluconate and glucose-1-phosphate. It was found that variation of Ca-P solubility exists between formulation with or without lipid emulsions. Concentrations of Ca decreased after filtrations of all admixtures (from 5% to 30%) and it was more significant in binary solutions. Precipitation has been observed by microscopy at high concentrations of both organic Ca-P after critical conditions of storage (24 h at 37 degrees C plus one day at ambient temperature) for admixtures containing 1% amino acids and 8% glucose with or without lipids compared to admixtures containing 2% or 3.5% amino acids and 14% glucose. These data demonstrated that availability of Ca using organic glucose-1-phosphate increased when lipids were present in TPN admixtures, without alteration of the lipid emulsion. Thus, high amounts of Ca (up to 30 mmol/l) and phosphates (up to 40 mmo...Continue Reading

References

Nov 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·B DunhamK Nichols
Jan 1, 1990·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M I BarnettD R Williams
Mar 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·J B KnowlesM D Sitrin
Nov 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·M RubinM Dintsman
Jul 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·F S Bettner, D J Stennett
Nov 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·R BrownR Sigman
Aug 1, 1993·Journal of Pharmaceutical Sciences·C WashingtonS E Irwin
Jan 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·S E HillJ C Perkinson
Sep 25, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·P A Ball
Jun 7, 2003·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Luis Pereira-da-SilvaMaria L Ribeiro
Sep 27, 2003·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·D F DriscollW Niemann
Dec 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·C L Ronchera-OmsJ Peidro

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Citations

Apr 15, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Hidehiko MaruyamaYushi Ito

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