Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro

Journal of Natural Products
Nassima Abdelouahab, Charles M Heard

Abstract

Harpagophytum procumbens, commonly known as Devil's Claw, is indigenous to southern Africa, and extracts of the tubers have been used for centuries in the treatment of a variety of inflammatory disorders. Its major active components, harpagoside (1), harpagide (2), 8-coumaroylharpagide (3), and verbascoside (4), are believed to interact either synergistically or antagonistically in modulating the enzymes responsible for inducing inflammation, although this has not been probed hitherto. In the current work, the ability of these compounds to inhibit the expression of COX-2 following administration to freshly excised porcine skin has been investigated. An ethanol-soluble extract of H. procumbens tubers and two of the pure compounds tested showed promising activity in Western blotting and immunocytochemical assays, with harpagoside (1) and 8-coumaroylharpagide (3) exhibiting greater reductions in COX-2 expression than verbascoside (4). Harpagide (2) caused a significant increase in the levels of COX-2 expression after 6 h of topical application. The data suggest that the efficacy of H. procumbens is dependent upon the ratios of compounds 1-4 present, which is inconsistent with some current official monograph specifications based so...Continue Reading

References

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Citations

Sep 9, 2009·Journal of Medicinal Food·Bong Hyun KimIl-Moo Chang
Aug 29, 2013·Neurochemical Research·Larissa Finger SchafferCaroline Wagner
Oct 3, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danae Carrillo-OcampoVerónica Rodríguez-López
May 7, 2013·Phytochemistry·Milen I GeorgievRobert Verpoorte
Jul 21, 2015·Natural Product Research·Carmela ParentiGiovanna M Scoto
Sep 4, 2012·Journal of Ethnopharmacology·Nontobeko MncwangiNigel Gericke
Jul 20, 2016·Oxidative Medicine and Cellular Longevity·Mbaki MuzilaCecilia Widén
Oct 27, 2009·Phytotherapy Research : PTR·Melainie CameronSigrun Chrubasik
Jul 18, 2019·Veterinary Medicine and Science·Nadia MuscoPietro Lombardi
Nov 1, 2017·Metabolomics : Official Journal of the Metabolomic Society·Korey J BrownsteinDavid R Gang
Sep 25, 2018·Frontiers in Pharmacology·Ali AttiqWaqas Ahmad
Oct 31, 2020·Fitoterapia·Claudio FrezzaMauro Serafini

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