PMID: 9179707Jun 1, 1997Paper

Effect of the menstrual cycle on gallbladder fasting volume and postprandial emptying in nulliparous young females

Investigative Radiology
E XynosN Gourtsoyiannis

Abstract

Reports on the effect of the ovulatory cycle on gallbladder motility are inconsistent. The authors investigated the gallbladder motor function at both phases of the menstrual cycle in humans. Seventeen young, healthy, nulliparous women participated in the study. Gallbladder fasting volume and postprandial emptying were measured twice in each subject using real-time ultrasonography: one at the follicular (12th-13th day) and another at the luteal (21st-22nd day) phases. From the emptying curves, the duration of the lag phase and the ejection fraction of emptying were calculated. Fasting volume was significantly greater (P = 0.025) at the luteal (14.8 +/- 8 mL standard deviation [SD]) than at the follicular (11.2 +/- 4.7 mL SD) phase. Although the lag phase duration was longer (P = 0.009) at the follicular (5.2 +/- 6.4 SD minutes) than the luteal (1.6 +/- 3.6 minutes SD) phase, the ejection fraction was significantly greater at the latter one (follicular phase: 62 +/- 13.2% SD; luteal phase: 73.4 +/- 14% SD; P = 0.0085). Female sex hormones seem to biologically affect the gallbladder motor function.

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Citations

Jul 6, 2004·The American Journal of Gastroenterology·Robert S FisherDavid L Earnest

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