PMID: 8594316Jan 1, 1996Paper

Effect of the neurotensin receptor antagonist SR48692 on rat blood pressure modulation by neurotensin

Life Sciences
D GullyJ P Maffrand

Abstract

When administered as an intravenous injection in the pentobarbitone-anaesthetized rat, neurotensin (NT) elicits a biphasic depressor-pressor effect that can be evaluated by the mean arterial blood pressure (MABP). The first hypotensive phase elicited by low doses of NT is dependent on the interaction of NT with its specific receptors and may be mediated by the release of histamine, since it is prevented by oral pretreatment with the selective NT receptor antagonist SR 48692 and by intravenous pretreatment with a selective H1 receptor antagonist mepyramine. The hypertensive effect evoked by higher doses of NT is histamine-independent but remains NT receptor- mediated. The prevention of the biphasic effect on MABP by oral administration of the NT receptor antagonist SR 48692 validates the implication of NT receptors in the histamine release phenomenon.

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Citations

Jul 11, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Katarzyna KaczyńskaAndrzej W Lipkowski
Apr 7, 1999·Progress in Retinal and Eye Research·M Coca-PradosJ Ortego
May 26, 2015·European Journal of Pharmacology·Oleg E Osadchii
Apr 29, 1998·Journal of Cardiovascular Pharmacology·P SchaefferJ M Herbert
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Eli-Anne B GjerdeRolf K Reed
Jun 18, 2019·Clinical and Experimental Hypertension : CHE·Ismail BolatMehmet Erturk
Jun 12, 2021·Neuropharmacology·Patricia Perez-BonillaGina M Leinninger

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