PMID: 1206391Jan 1, 1975Paper

Effect of the norepinephrine receptor stimulating agent "clonidine" on the turnover of 5-hydroxytryptamine in some areas of the rat brain

Journal of Neural Transmission
L Rochette, J Bralet

Abstract

The effect of clonidine (0.05 mg/kg i.p.) on 5-hydroxytryptamine (5-HT) turnover has been studied in the whole brain and in various cerebral areas of the rat (brain stem, hypothalamus, striatum and "rest" of the brain). In the whole brain, clonidine produced a significant decrease (-23%) in 5-hydroxyindole acetic acid level and a slight increase (+7%) in 5-HT level. These variations were not observed in all the cerebral structures. The 5-hydroxyindole acetic acid levels were reduced in the hypothalamus and in the rest of the brain; they were not significantly altered in the brain stem and increased in the striatum. The effect of clonidine on the 5-HT synthesis has been studied by evaluation of the rises in 5-HT levels induced by pargyline: these rises were found significantly increased in the brain stem and the hypothalamus and not significantly altered in the other cerebral structures. These findings give support to the hypothesis according to which the norepinephrine receptor stimulation inhibits the activtity in the 5-HT neurons: clonidine reduces primarily the relase of 5-HT without an immediate effect on its synthesis. The differences observed among the various cerebral areas might be explained by the fact that relations b...Continue Reading

References

Jan 15, 1975·Biochemical Pharmacology·L Brochette, J Bralet
Apr 1, 1973·The Journal of Pharmacy and Pharmacology·P Bolme, K Fuxe
May 1, 1970·Life Sciences·N E AndénT Svensson
Sep 1, 1973·European Journal of Pharmacology·J Bralet, L Rochette

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Citations

Mar 29, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·C J PycockC D Marsden
Jun 1, 1985·Electroencephalography and Clinical Neurophysiology·O Kanno, P Clarenbach
Jan 25, 1991·European Journal of Pharmacology·J C GarrattC A Marsden
Jan 1, 1988·Journal of Psychiatric Research·S K BhattacharyaK P Datla
Jun 1, 1987·Behavioural Brain Research·M R PranzatelliS R Snodgrass
Jan 14, 1987·Neuroscience Letters·M VallejoS L Lightman
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·D N FranzR J Neumayr
Jul 7, 1980·Brain Research·A Leppävuori, P T Putkonen
Sep 1, 1977·The Journal of Pharmacy and Pharmacology·J Vetulani, B Bednarczyk
Jan 1, 1980·Acta Psychiatrica Scandinavica. Supplementum·B TabakoffP L Hoffman
Sep 1, 1975·Journal of Medical Ethics·D G Grahame-Smith

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