Effect of the normalization of TSH and free T4 on lipid profile in a pediatric population with primary hypothyroidism.

Andes Pediatrica : Revista Chilena De Pediatría
Aleida Rivera-HernándezLourdes Balcázar-Hernández

Abstract

Hypothyroidism has been associated with dyslipidemia. Its treatment with levothyroxine has shown a positive effect on the lipid profile in adults, however, there is a lack of data on the pediatric popu lation. to evaluate the effect of the thyroid profile normalization on the lipid profile in children with primary hypothyroidism. Retrospective study in children aged from 6 to 16 years, with diagnosis of primary hypothyroidism due to Hashimoto's thyroiditis, in treatment with levothyroxine, and who had an evaluation of serum lipids before and during their treatment. The lipid profile was evaluated in 2 stages: the first one referred to as "before levothyroxine treatment" (at the diagnosis of primary hypothyroidism) and the second one referred to as " thyroid profile normalization" (when normalization of Thyroid-stimulating hormone [TSH] and free T4 [FT4] was achieved during levothyroxine treatment). Sociodemographic and anthropometric data were recorded. The lipid profile evaluation consisted of the serum determination of total cholesterol (TC), high-density cholesterol (HDL-C), and TG. The phenotype of dyslipidemias was determined according to the Fredrickson's classification. 72 patients were included (61% women; age 11.5 ± 2....Continue Reading

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